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Database: UniProt
Entry: B6YXB2_THEON
LinkDB: B6YXB2_THEON
Original site: B6YXB2_THEON 
ID   B6YXB2_THEON            Unreviewed;       303 AA.
AC   B6YXB2;
DT   20-JAN-2009, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2009, sequence version 1.
DT   18-JUL-2018, entry version 72.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000256|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000256|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000256|HAMAP-Rule:MF_00383};
GN   OrderedLocusNames=TON_1237 {ECO:0000313|EMBL:ACJ16725.1};
OS   Thermococcus onnurineus (strain NA1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=523850 {ECO:0000313|EMBL:ACJ16725.1, ECO:0000313|Proteomes:UP000002727};
RN   [1] {ECO:0000313|EMBL:ACJ16725.1, ECO:0000313|Proteomes:UP000002727}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA1 {ECO:0000313|EMBL:ACJ16725.1,
RC   ECO:0000313|Proteomes:UP000002727};
RX   PubMed=18790866; DOI=10.1128/JB.00746-08;
RA   Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H.,
RA   Cha S.S., Kwon K.K., Kim H.T., Park C.J., Lee H.W., Kim S.I., Chun J.,
RA   Colwell R.R., Kim S.J., Lee J.H.;
RT   "The complete genome sequence of Thermococcus onnurineus NA1 reveals a
RT   mixed heterotrophic and carboxydotrophic metabolism.";
RL   J. Bacteriol. 190:7491-7499(2008).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter.
CC       Also responsible for recruiting RNA polymerase II to the pre-
CC       initiation complex (DNA-TBP-TFIIB). {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00383};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00383};
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; CP000855; ACJ16725.1; -; Genomic_DNA.
DR   RefSeq; WP_012572197.1; NC_011529.1.
DR   STRING; 523850.TON_1237; -.
DR   EnsemblBacteria; ACJ16725; ACJ16725; TON_1237.
DR   GeneID; 7018260; -.
DR   KEGG; ton:TON_1237; -.
DR   PATRIC; fig|523850.10.peg.1244; -.
DR   eggNOG; arCOG01981; Archaea.
DR   eggNOG; COG1405; LUCA.
DR   HOGENOM; HOG000108633; -.
DR   KO; K03124; -.
DR   OMA; NEIARTY; -.
DR   OrthoDB; POG093Z07LX; -.
DR   BioCyc; TONN523850:G1GAB-1269-MONOMER; -.
DR   Proteomes; UP000002727; Chromosome.
DR   GO; GO:0003700; F:DNA binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:DNA-templated transcriptional preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 2.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 2.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002727};
KW   Initiation factor {ECO:0000313|EMBL:ACJ16725.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Protein biosynthesis {ECO:0000313|EMBL:ACJ16725.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002727};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT   DOMAIN        3     34       TFIIB-type. {ECO:0000259|PROSITE:
FT                                PS51134}.
FT   REPEAT      120    203       1. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   REPEAT      214    295       2. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   ZN_FING       3     34       TFIIB-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00469}.
FT   COILED      108    128       {ECO:0000256|SAM:Coils}.
FT   COILED      223    243       {ECO:0000256|SAM:Coils}.
FT   METAL         7      7       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        10     10       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        26     26       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        29     29       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
SQ   SEQUENCE   303 AA;  34301 MW;  4F18BE4EADA45916 CRC64;
     MADKNICPVC GSDKLFYDPR RGEIVCSVCG YVVQQNVIDE GPEWRAFDPD QRTKRARTGA
     PMTLMIHDKG LSTDIDWRDR DIHGNQITGM YRTKMRRLRM WQRRMRINDA AERNLAFALS
     ELDRMAAQMM LPRRVKEVAA SLYRKAVMKK LIRGRSIEGM VSAALYAACR MEGIPRTLDE
     IAAVSKVTKK EIGRSYRFLA RGLGLNLRPT SPIEYIDRFG DSLDVSQRTK KRAKEILQEA
     IKRGITSGKG PTGLAAAALY VASLLEGEKK TQREVAEVAH VTEVTVRNRY KELVEKLGIN
     VPI
//
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