ID B7C779_9FIRM Unreviewed; 392 AA.
AC B7C779;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Sugar isomerase, AgaS family {ECO:0000313|EMBL:EEC91364.1};
GN ORFNames=EUBIFOR_00026 {ECO:0000313|EMBL:EEC91364.1};
OS Holdemanella biformis DSM 3989.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Erysipelotrichaceae; Holdemanella.
OX NCBI_TaxID=518637 {ECO:0000313|EMBL:EEC91364.1, ECO:0000313|Proteomes:UP000004315};
RN [1] {ECO:0000313|EMBL:EEC91364.1, ECO:0000313|Proteomes:UP000004315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3989 {ECO:0000313|EMBL:EEC91364.1,
RC ECO:0000313|Proteomes:UP000004315};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEC91364.1, ECO:0000313|Proteomes:UP000004315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3989 {ECO:0000313|EMBL:EEC91364.1,
RC ECO:0000313|Proteomes:UP000004315};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Eubacterium biforme (DSM 3989).";
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-
CC phosphate + NH4(+); Xref=Rhea:RHEA:47680, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:71674, ChEBI:CHEBI:138150;
CC Evidence={ECO:0000256|ARBA:ARBA00029292};
CC -!- SIMILARITY: Belongs to the SIS family. AgaS subfamily.
CC {ECO:0000256|ARBA:ARBA00007748}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEC91364.1}.
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DR EMBL; ABYT01000005; EEC91364.1; -; Genomic_DNA.
DR RefSeq; WP_003863843.1; NZ_DS996837.1.
DR AlphaFoldDB; B7C779; -.
DR STRING; 518637.EUBIFOR_00026; -.
DR GeneID; 66578612; -.
DR eggNOG; COG2222; Bacteria.
DR HOGENOM; CLU_012520_0_0_9; -.
DR OrthoDB; 9779207at2; -.
DR Proteomes; UP000004315; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR CDD; cd05010; SIS_AgaS_like; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035464; SIS_AgaS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR32502:SF3; D-GALACTOSAMINE-6-PHOSPHATE DEAMINASE AGAS-RELATED; 1.
DR PANTHER; PTHR32502; N-ACETYLGALACTOSAMINE PERMEASE II COMPONENT-RELATED; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:EEC91364.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 46..197
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 222..371
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 392 AA; 43719 MW; 3810FF0055102BFE CRC64;
MFGKEKSTWE ELSGIFTAQE IYQQPATWAK TIAQIKNEKE ALKKFMEPVL SDPDCDIVFT
GAGTSEYVGN ALYSYVNRYT GYHAKSYAST DLVETPENYL SRNKKTLLVN FGRSGNSPES
VGSVQVADEV CKENVYHLFI TCNKDGALAK AAATRDNAYD INLTPETHDQ SFAMTSSFSN
MMLAALLCFR LDDIDEVAKE MESVIAQGQK FVDEGYKVCE DLVADFAEFN RIVYLGANTL
KGIAQESQLK ICELTAGTVT TTFDSPMGFR HGPKSVINDE CLTVVYLSDD EYQRQYEYDI
IKEMSGQRKK NRLVAVSSHA DAEIEGLVDT FINFDLDAPK DNIFLGFDYI LVAQVIALFK
SLSYKITPDN PCPTGEVNRV VKGVTIYPYT AK
//
