ID B7FYG1_PHATC Unreviewed; 1108 AA.
AC B7FYG1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=E1 ubiquitin-activating enzyme {ECO:0000256|ARBA:ARBA00012990};
DE EC=6.2.1.45 {ECO:0000256|ARBA:ARBA00012990};
DE Flags: Fragment;
GN Name=UBA1 {ECO:0000313|EMBL:EEC48718.1};
GN ORFNames=PHATRDRAFT_54460 {ECO:0000313|EMBL:EEC48718.1};
OS Phaeodactylum tricornutum (strain CCAP 1055/1).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Bacillariophyceae; Bacillariophycidae; Naviculales; Phaeodactylaceae;
OC Phaeodactylum.
OX NCBI_TaxID=556484 {ECO:0000313|EMBL:EEC48718.1, ECO:0000313|Proteomes:UP000000759};
RN [1] {ECO:0000313|EMBL:EEC48718.1, ECO:0000313|Proteomes:UP000000759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCAP 1055/1 {ECO:0000313|EMBL:EEC48718.1,
RC ECO:0000313|Proteomes:UP000000759};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
RN [2] {ECO:0000313|Proteomes:UP000000759}
RP GENOME REANNOTATION.
RC STRAIN=CCAP 1055/1 {ECO:0000313|Proteomes:UP000000759};
RG Diatom Consortium;
RA Grigoriev I., Grimwood J., Kuo A., Otillar R.P., Salamov A., Detter J.C.,
RA Lindquist E., Shapiro H., Lucas S., Glavina del Rio T., Pitluck S.,
RA Rokhsar D., Bowler C.;
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
CC = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-
CC L-cysteine.; EC=6.2.1.45; Evidence={ECO:0000256|ARBA:ARBA00000488};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR EMBL; CM000610; EEC48718.1; -; Genomic_DNA.
DR RefSeq; XP_002179732.1; XM_002179696.1.
DR AlphaFoldDB; B7FYG1; -.
DR STRING; 556484.B7FYG1; -.
DR TCDB; 3.A.25.1.1; the symbiont-specific erad-like machinery (selma) family.
DR PaxDb; 2850-Phatr5043; -.
DR GeneID; 7200448; -.
DR KEGG; pti:PHATRDRAFT_54460; -.
DR eggNOG; KOG2012; Eukaryota.
DR HOGENOM; CLU_002556_0_0_1; -.
DR InParanoid; B7FYG1; -.
DR OrthoDB; 36498at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000759; Chromosome 7.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR PANTHER; PTHR10953:SF4; UBA_E1_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000000759};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1108
FT /note="E1 ubiquitin-activating enzyme"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002852814"
FT DOMAIN 947..1101
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
FT NON_TER 1108
FT /evidence="ECO:0000313|EMBL:EEC48718.1"
SQ SEQUENCE 1108 AA; 123352 MW; 6C0F8592122D613A CRC64;
MNYCWRFCLG LLLEQALLRD SFGVRFVPIF HPSPRRVKVH IRNALSSRGG GGGDAVGETE
DDEERYSRQV FALGAEAHKR IRSSTVYLDG PGLDAAYFKG ELDDLGRAYH RAARSETGKS
DDDCDVSDEE VLMEYLKRLN PSVQVSVVKY SDFRPLDDSL RGVLLCVDRC HEKLLVMNGL
ARRHNLAFVG TETAGVYGRV FCDFGTSFEV NDTDGETPLV IPLDRVERGI SDEILFVTCL
EGQQHDVSKG EEIRFIDPNG DSSEQKCTVI EVHTPLRLSI EVDKKGGSCQ EWIESVNKKY
VAFSRIKASK KLSFDDLAIA SKKASSDASI FTPSDLGKSF DDNRRAALFA CFRAASSFVG
DHLRWADDND LDDFCELVRT FMSNCESEHC FLSESQHFNV EQFLEVGRAK FSPIQAFFGA
IASQEALKAL TGLYHPIQQF LLYDCDEILN SPSDRTCSVN EKEGSDRNTC GLRHILGDSI
VEDLQSMRVF VVGAGAIGCE ILKNLAAMGI GSKSKGRVII TDMDTIEKSN LSRQLLFRDS
DVGKFKSSAA TQAILRFNNK MKIDSHSSKV GDSEHNPFDD LFWRKGVDIV LNALDNMEAR
FFTDRQCVAN GKPLIDSGTL GPKGNVQVVI PHKSESYSSS ADPPDPAIAV CTLKNFPYAI
SHTIQWGRDL FEDVFSRRPS QVNDARDSLS STCVEAFVSR LIQERGENGF QQFAAELKED
VSPDLESSDI RAHSLEWAAS TAVKLFRDSI ETLLLKHPPG SLDDDGEPFW SGTRRQPRVL
SFSGSVPLDA MQSSVNENLI DFVRYAARLR AEMYASKPIR DPFEFSRNDA EASLNSAEQA
QPSDKEVMDT DTVNVLIDSL RRLSSFSKPL NTAEFEKDDD SNGHIAFVTA ASNLRAMSYG
IPPVNRLQTR RIAGNIVPAV ISTTAAVSAL SCIELVKLAQ GAQLKLHRNA FMNLALPFFA
FTSPLPAEVM PGLQGRQYTI WDRLKVRESK KALAKGGISL RKLIRRIKQL ASTNPKKVSV
LSISFGPYLL YASFLHDDDK NHLKSSLWNI LEELTEVDDD FVSTRSNDNR STEYSPTQKF
VDLSVIVEDP DNGSECELPL VRVFRRFL
//
