ID B7IDX4_THEAB Unreviewed; 706 AA.
AC B7IDX4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN OrderedLocusNames=THA_1770 {ECO:0000313|EMBL:ACJ76201.1};
OS Thermosipho africanus (strain TCF52B).
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Fervidobacteriaceae;
OC Thermosipho.
OX NCBI_TaxID=484019 {ECO:0000313|EMBL:ACJ76201.1, ECO:0000313|Proteomes:UP000002453};
RN [1] {ECO:0000313|EMBL:ACJ76201.1, ECO:0000313|Proteomes:UP000002453}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TCF52B {ECO:0000313|EMBL:ACJ76201.1,
RC ECO:0000313|Proteomes:UP000002453};
RX PubMed=19124572; DOI=10.1128/JB.01448-08;
RA Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D.,
RA Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.;
RT "The genome of Thermosipho africanus TCF52B: lateral genetic connections to
RT the Firmicutes and Archaea.";
RL J. Bacteriol. 191:1974-1978(2009).
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
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DR EMBL; CP001185; ACJ76201.1; -; Genomic_DNA.
DR RefSeq; WP_012580398.1; NC_011653.1.
DR AlphaFoldDB; B7IDX4; -.
DR STRING; 484019.THA_1770; -.
DR KEGG; taf:THA_1770; -.
DR eggNOG; COG0557; Bacteria.
DR HOGENOM; CLU_002333_4_1_0; -.
DR OrthoDB; 9764149at2; -.
DR Proteomes; UP000002453; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 622..702
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 706 AA; 80482 MW; 4FA885A3EDF97DCB CRC64;
MINKKKLESF FNSSSYKPMI QKEIYNALKI KNKDEKKIVR KLLKELQNEG KIYKDSKGRY
KVIGKNMIVG TIEFTRNGTM AFVWTENGEE IAVPAEKAGR AIHKDKVVVE ITGKWYDIPE
GRVVKILDHG LKKVVGTFQP IGRAAFIIPD DPKIQYDFYV PIEFFNNAKP GEKVVGKIIK
YPTPTKNPVA KIIEVLGYAD DPATDFPTVV VKHDLPLEFP DKVLKEASKI PDRILEKDLR
NRKDFRNEIV VTIDGPDAKD FDDAVSVKKL KNDNYLLGVH IADVSHYVKE GSELDKEAFK
RGTSVYLIDR VLPMLPFKLS HGICSLVQGE DRLVMSLVME IDREGNVVDF EVAPGVIRSH
RRLVYDDVNA LFKGDKVAFN KIGDLYDQLI LMKELKDVLR NARKRRGAIL DIEGGEVKII
LDEKGNTIDI IPRERGEAEV IIEEFMIKAN ETIAELFYNF DLPFVYRIHE KPDPDTIIQL
KNYLSAIGIS FKVPKKITSK LLQELLEKTK NHPLRGSIER LLVRSMKRAV YSANNIGHFG
LASYAYTHFT SPIRRYPDLV VHRLIKQFLS TNGKLTKKEI TKLNDKLSKI AVHSSKRERV
ADEAEWDYTA LKKIDYISKH IGETFDVVVT AVTKFGLFVE IIDKNISGLI HISTLDDYFL
YDEERSILIG SHTGKVFKIG DKLKAKVVNA NKTRMQIDFE IAKSEA
//
