ID OSPA_BORBZ Reviewed; 273 AA.
AC B7IZU3; P14013; Q44882; Q44964; Q44967; Q44969; Q44971; Q57123; Q57272;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Outer surface protein A {ECO:0000303|PubMed:2587225};
DE Flags: Precursor;
GN Name=ospA {ECO:0000303|PubMed:2587225}; OrderedLocusNames=BbuZS7_A13;
OS Borreliella burgdorferi (strain ZS7) (Borrelia burgdorferi).
OG Plasmid ZS7_lp54.
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC Borreliella.
OX NCBI_TaxID=445985;
RN [1] {ECO:0000312|EMBL:CAA34487.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ZS7;
RX PubMed=2587225; DOI=10.1093/nar/17.21.8864;
RA Wallich R., Schaible U.E., Simon M.M., Heiberger A., Kramer M.D.;
RT "Cloning and sequencing of the gene encoding the outer surface protein A
RT (OspA) of a European Borrelia burgdorferi isolate.";
RL Nucleic Acids Res. 17:8864-8864(1989).
RN [2] {ECO:0000312|EMBL:ACK74228.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZS7;
RX PubMed=20935092; DOI=10.1128/jb.01158-10;
RA Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J.,
RA Mongodin E.F., Luft B.J.;
RT "Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.";
RL J. Bacteriol. 193:1018-1020(2011).
RN [3]
RP PROTEIN SEQUENCE OF 118-135, AND SUBCELLULAR LOCATION.
RC STRAIN=ZS7;
RX PubMed=1829104; DOI=10.1093/infdis/164.1.123;
RA Simon M.M., Schaible U.E., Kramer M.D., Eckerskorn C., Museteanu C.,
RA Muller-Hermelink H.K., Wallich R.;
RT "Recombinant outer surface protein a from Borrelia burgdorferi induces
RT antibodies protective against spirochetal infection in mice.";
RL J. Infect. Dis. 164:123-132(1991).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305|PubMed:2587225};
CC Lipid-anchor {ECO:0000255|PROSITE-ProRule:PRU00303}. Cell surface
CC {ECO:0000269|PubMed:1829104}.
CC -!- SIMILARITY: Belongs to the OspA lipoprotein family. {ECO:0000305}.
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DR EMBL; X16467; CAA34487.1; -; Genomic_DNA.
DR EMBL; CP001199; ACK74228.1; -; Genomic_DNA.
DR PIR; S14906; MMLYAZ.
DR RefSeq; WP_012615002.1; NC_011784.1.
DR AlphaFoldDB; B7IZU3; -.
DR BMRB; B7IZU3; -.
DR SMR; B7IZU3; -.
DR KEGG; bbz:BbuZS7_A13; -.
DR HOGENOM; CLU_1014382_0_0_12; -.
DR Proteomes; UP000006901; Plasmid ZS7_lp54.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR Gene3D; 3.90.930.1; -; 1.
DR Gene3D; 2.40.128.160; C1 set domains (antibody constant domain-like); 1.
DR InterPro; IPR001809; OM_lipoprot_Borrelia.
DR InterPro; IPR023322; OM_lipoprot_dom_sf.
DR Pfam; PF00820; Lipoprotein_1; 1.
DR PRINTS; PR00968; OUTRSURFACE.
DR SUPFAM; SSF51087; Outer surface protein; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Direct protein sequencing; Lipoprotein; Membrane;
KW Palmitate; Plasmid; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 17..273
FT /note="Outer surface protein A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT /id="PRO_0000370271"
FT LIPID 17
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 17
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 273 AA; 29455 MW; 0889191B09F45EC2 CRC64;
MKKYLLGIGL ILALIACKQN VSSLDEKNSV SVDLPGEMNV LVSKEKNKDG KYDLIATVDK
LELKGTSDKN NGSGVLEGVK ADKSKVKLTI SDDLGQTTLE VFKEDGKTLV SKKVTSKDKS
STEEKFNEKG EVSEKIITRA DGTRLEYTEI KSDGSGKAKE VLKSYVLEGT LTAEKTTLVV
KEGTVTLSKN ISKSGEVSVE LNDTDSSAAT KKTAAWNSGT STLTITVNSK KTKDLVFTKE
NTITVQQYDS NGTKLEGSAV EITKLDEIKN ALK
//
