ID MUTL_RIPO1 Reviewed; 561 AA.
AC B7JY11;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN OrderedLocusNames=PCC8801_1937;
OS Rippkaea orientalis (strain PCC 8801 / RF-1) (Cyanothece sp. (strain PCC
OS 8801)).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Aphanothecaceae; Rippkaea; Rippkaea orientalis.
OX NCBI_TaxID=41431;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 8801 / RF-1;
RX PubMed=21972240; DOI=10.1128/mbio.00214-11;
RA Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA Sherman L.A., Pakrasi H.B.;
RT "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT unicellular nitrogen-fixing Cyanobacteria.";
RL MBio 2:E214-E214(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP001287; ACK65975.1; -; Genomic_DNA.
DR RefSeq; WP_012595247.1; NC_011726.1.
DR AlphaFoldDB; B7JY11; -.
DR SMR; B7JY11; -.
DR STRING; 41431.PCC8801_1937; -.
DR KEGG; cyp:PCC8801_1937; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_3; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000008204; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..561
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000192168"
SQ SEQUENCE 561 AA; 62754 MW; 5A881610E615D0EF CRC64;
MSSPIQPLPL NVINLIAAGE VIDSIAAVVR ELVENALDAG ATRLVISLFP ESWRVQVADN
GTGMTLADLR HCALPHSTSK IHQLDDLWKI TTLGFRGEAL HSLAQVADLE IASRCTSDGV
GWCLRYQSSG EPLREEPTAI APGTIVTVGN LFGKMPVRRQ GLPAISTQLK AVQSFIENMA
LCHPQVTWQV WHNQRLWLNI SPGKTPQQIL PQLLKGVHYH DLQFVSQGVK SPQESTQKDL
DLIEVTLGLP DRCHRHRPDW VKVGINGRIV RSPPVEQAIL VAFSRTLPKD RFPVCFIHLT
LCPSQIDWNR HPAKVEIYLH SLDFWQEQVS KLIEQGLRLS PQTLASAAQN QRVGKLLKAS
EEKASYRVDA KDHQTDANAV GLMPLKAVAQ VRNTYIMAEH STGLWLIEQH IAHERVLYET
LQDNWQLIPL ETPIILTKLS DNQVEQLARI GLEIEVFGEQ LWAVRTVPKL LSTREDCPEA
LVELSIGGDL QTAQVAVACR SAIRNGTPMT LSQMQELLDQ WKTTRNPATC PHGRPIYLSL
EESSLSRFFR RHWVIGKSHG I
//
