ID B7KFY9_GLOC7 Unreviewed; 512 AA.
AC B7KFY9;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Thymidylate synthase {ECO:0000313|EMBL:ACK69182.1};
GN OrderedLocusNames=PCC7424_0726 {ECO:0000313|EMBL:ACK69182.1};
OS Gloeothece citriformis (strain PCC 7424) (Cyanothece sp. (strain PCC
OS 7424)).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Aphanothecaceae; Gloeothece; Gloeothece citriformis.
OX NCBI_TaxID=65393 {ECO:0000313|EMBL:ACK69182.1, ECO:0000313|Proteomes:UP000002384};
RN [1] {ECO:0000313|Proteomes:UP000002384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7424 {ECO:0000313|Proteomes:UP000002384};
RX PubMed=21972240; DOI=10.1128/mBio.00214-11;
RA Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H.,
RA Sherman L.A., Pakrasi H.B.;
RT "Novel metabolic attributes of the genus Cyanothece, comprising a group of
RT unicellular nitrogen-fixing Cyanobacteria.";
RL MBio 2:E214-E214(2011).
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DR EMBL; CP001291; ACK69182.1; -; Genomic_DNA.
DR RefSeq; WP_012598129.1; NC_011729.1.
DR AlphaFoldDB; B7KFY9; -.
DR STRING; 65393.PCC7424_0726; -.
DR KEGG; cyc:PCC7424_0726; -.
DR eggNOG; COG0207; Bacteria.
DR HOGENOM; CLU_042142_0_0_3; -.
DR OrthoDB; 427400at2; -.
DR Proteomes; UP000002384; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR025595; DUF4346.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF14251; DUF4346; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002384};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 268..408
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT DOMAIN 446..498
FT /note="DUF4346"
FT /evidence="ECO:0000259|Pfam:PF14251"
SQ SEQUENCE 512 AA; 58448 MW; 35B5DA5EA293309B CRC64;
MTFVTGEHTT YYKPICKSNQ LICGYGHIAL ITGWTVKQTL VKHLSPKEFA VIGNLYSPTR
GITPLIRNLL ANPHVRFVVI LNATQEDKNA GACDCLLDFF RNGFQEGKSD TGRKCWLINS
ETKGYIDFEI DAKALDILRN SIRWEEVKTI SEAVSRVKFF SQNKNVEAWG NPLEFKEVVT
ISHVLPGSRY GHRIEGQTIA ETWIKILHKI RKTGTIRNTE YGEWQELIDI MAIVTDEPSD
FYFPEPNYLS IERQNLQNYI EQMLSDLSSQ EGVEYTYGKR LRSWFKQDQI EQVIKKLTLD
INSSRAVMSL WDVHDHEGND NPPCLNHIWL RVVENELSLT ATFRSNDMFS AWPANAMGLR
ALQQHILDNI NQRASYSLKM GPLITVSQSA HIYSDCWEYA DRLIDEQYAK ICQKRDFNDP
SGSFVITLQN NTIIVEHTTP GTGEIVNCYT GKSARKLYQQ IASNCPSLQV EHAMYLGTEL
QKAEIALSNS QTYLYIQDQP LSILTKAIKP VG
//
