GenomeNet

Database: UniProt
Entry: B7L425
LinkDB: B7L425
Original site: B7L425 
ID   ECPR_ECO55              Reviewed;         196 AA.
AC   B7L425;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   13-NOV-2019, entry version 67.
DE   RecName: Full=HTH-type transcriptional regulator EcpR;
GN   Name=ecpR; Synonyms=matA; OrderedLocusNames=EC55989_0298;
OS   Escherichia coli (strain 55989 / EAEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=55989 / EAEC;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A.,
RA   Chiapello H., Clermont O., Cruveiller S., Danchin A., Diard M.,
RA   Dossat C., Karoui M.E., Frapy E., Garry L., Ghigo J.M., Gilles A.M.,
RA   Johnson J., Le Bouguenec C., Lescat M., Mangenot S.,
RA   Martinez-Jehanne V., Matic I., Nassif X., Oztas S., Petit M.A.,
RA   Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J., Vacherie B.,
RA   Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
CC       common pilus (ECP). ECP is found in both commensal and pathogenic
CC       strains and plays a dual role in early-stage biofilm development
CC       and host cell recognition. Positively regulates the expression of
CC       the ecp operon (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively autoregulated.
CC       Also positively regulated by IHF (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpR/MatA family. {ECO:0000305}.
DR   EMBL; CU928145; CAU96176.1; -; Genomic_DNA.
DR   SMR; B7L425; -.
DR   PRIDE; B7L425; -.
DR   EnsemblBacteria; CAU96176; CAU96176; EC55989_0298.
DR   KEGG; eck:EC55989_0298; -.
DR   HOGENOM; HOG000059412; -.
DR   KO; K21963; -.
DR   OMA; CIWPAHD; -.
DR   BioCyc; ECOL585055:EC55989_RS01535-MONOMER; -.
DR   Proteomes; UP000000746; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Complete proteome; Cytoplasm; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    196       HTH-type transcriptional regulator EcpR.
FT                                /FTId=PRO_0000369172.
FT   DOMAIN      138    196       HTH luxR-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
FT   DNA_BIND    162    181       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00411}.
SQ   SEQUENCE   196 AA;  23273 MW;  CAB6AFF0919883B7 CRC64;
     MTWQSDYSRD YEVKNHMECQ NRSDKYIWSP HDAYFYKGLS ELIVDIDRLI YLSLEKIRKD
     FVFINLNTDS LSEFINRDNE WLSAVKGKQV VLIAARKSEA LANYWYYNSN IRGVVYAGLS
     RDIRKELAYV INGRFLRKDI KKDKITDREM EIIRMTAQGM QPKSIARIEN CSVKTVYTHR
     RNAEAKLYSK IYKLVQ
//
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