ID B7P0N6_IXOSC Unreviewed; 480 AA.
AC B7P0N6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Inward rectifier K+ channel, putative {ECO:0000313|EMBL:EEC00166.1, ECO:0000313|EnsemblMetazoa:ISCW016219-PA};
GN ORFNames=IscW_ISCW016219 {ECO:0000313|EMBL:EEC00166.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC00166.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC00166.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016219-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016219-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010007156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010174038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010369636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011081859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS612847; EEC00166.1; -; Genomic_DNA.
DR RefSeq; XP_002399317.1; XM_002399276.1.
DR AlphaFoldDB; B7P0N6; -.
DR STRING; 6945.B7P0N6; -.
DR PaxDb; 6945-B7P0N6; -.
DR EnsemblMetazoa; ISCW016219-RA; ISCW016219-PA; ISCW016219.
DR KEGG; isc:IscW_ISCW016219; -.
DR VEuPathDB; VectorBase:ISCI016219; -.
DR VEuPathDB; VectorBase:ISCP_002534; -.
DR VEuPathDB; VectorBase:ISCW016219; -.
DR HOGENOM; CLU_022738_3_1_1; -.
DR InParanoid; B7P0N6; -.
DR OMA; ETQICVS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR041647; IRK_C.
DR InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR InterPro; IPR040445; Kir_TM.
DR PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR11767:SF102; INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F; 1.
DR Pfam; PF01007; IRK; 1.
DR Pfam; PF17655; IRK_C; 1.
DR PRINTS; PR01320; KIRCHANNEL.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 1: Evidence at protein level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003822};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW ECO:0000256|RuleBase:RU003822};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P0N6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003822};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003822}.
FT TRANSMEM 137..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..239
FT /note="Potassium channel inwardly rectifying transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01007"
FT DOMAIN 246..417
FT /note="Inward rectifier potassium channel C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17655"
FT REGION 20..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 54273 MW; 6DC68FD151B2E9F2 CRC64;
MKFVEMENGQ AWQQLISRSH GLNPSAAGGG AGDSDYDTPS NQGESSTSSR RILTKHLSLN
GFPRCADGGD GVGGGNADDS PVVRYQKAKI IPSRARKRVI FKNGSVNLSK EHVYKRSQRY
LQDIFTTLVD IQWRWNLMVF SMGFILSWLV FAIIWWLIMF AHGDFDPHEG DWTPCIVDVT
SFTSAFLFSL ETQHTIGYGS RAITPECPEA VFILCMQSIT GVMIQCFMAG IVFAKLSRPK
KRSQTLLFSR NAVVCLRDGK LCLLFRVGDM RKSHIIGTNI AAQIIRRKVT AEGEVIPYYH
TQLDVRFDAG SDSILFIWPA TIVHEIGETS PFYNMSAEDV LREKFEIVVI LEGTIESTGQ
SIQARSSYLP SELLWGHRFE QLVRFQKDSS EYLVDYSKFN NTYEVETPLC SARDFYEYQR
MLRNAPRMVA LKFSRELEES PKQTQTARVT IRRGPIIKCH HVIGEAPSPA QPTHNDKPQA
//
