ID B7P170_IXOSC Unreviewed; 551 AA.
AC B7P170;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=IscW_ISCW016113 {ECO:0000313|EMBL:EEC00342.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC00342.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC00342.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016113-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016113-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010344775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010382518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010467218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010474531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010638971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010781682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010789358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011110304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011113817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS615069; EEC00342.1; -; Genomic_DNA.
DR RefSeq; XP_002400556.1; XM_002400512.1.
DR AlphaFoldDB; B7P170; -.
DR STRING; 6945.B7P170; -.
DR PaxDb; 6945-B7P170; -.
DR EnsemblMetazoa; ISCW016113-RA; ISCW016113-PA; ISCW016113.
DR KEGG; isc:IscW_ISCW016113; -.
DR VEuPathDB; VectorBase:ISCI016113; -.
DR VEuPathDB; VectorBase:ISCP_029381; -.
DR VEuPathDB; VectorBase:ISCW016113; -.
DR HOGENOM; CLU_621990_0_0_1; -.
DR InParanoid; B7P170; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 351..386
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 551 AA; 64014 MW; D3190FED4729FC3D CRC64;
MVYGYWDGVD VPYDLSNSEE LTRSHNTELN SPCGEIPPDR LAKCWQLNYH EAAIFLEEGQ
NNDKLDFHPC SHAALPAYLV VHNRLFYCLD LLSAVVLMSL ALMEEPALPG LDVPIAFHVA
VELLALCVVA AELVMKLRWL GLRPFFAHKR TVFKLTILLL MFVEALVVAA RQTNHFRVLR
ALRPIFLIDN HYLGGVRRLT RQILQSLPPV FDMLVILFFF MTMFAILAYH MFAAAPEQYF
STLYDSFMNL FVLLTTSNFP DVMIPYYARS KWASLFFVVF LLVHLYFLMN LVLAVVYERF
SSLEKDKFRK LLLHRRKACQ QAFRLLVNRT SPSCLYFCHF EGLMRYYKPR AKRREVYLMF
KTMDVSRNGF LSQEDFLQVL FQLKKSYHDV LGTVFILMPR FLSVGLVLIV VYYFFAIIGI
EVFSGYQMED CCNRHLASLH PPEDNLVRVE TRMSKAEIAL CSDPTPHPPA PEPLNYATDA
AADTLVFRGV RWRTKFSFCL KMYAEEVKEW LDHAELEERR SNEWLILNVQ NREGDSTALE
AGHESRRTFT L
//
