ID   B7P1K8_IXOSC            Unreviewed;       605 AA.
AC   B7P1K8;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=Vacuolar protein sorting-associated protein 52 homolog {ECO:0000256|ARBA:ARBA00017083};
GN   ORFNames=IscW_ISCW015564 {ECO:0000313|EMBL:EEC00480.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC00480.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC00480.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW015564-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW015564-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS52 family.
CC       {ECO:0000256|ARBA:ARBA00008180}.
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DR   EMBL; ABJB010251910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010963690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB011131290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS616928; EEC00480.1; -; Genomic_DNA.
DR   RefSeq; XP_002433416.1; XM_002433371.1.
DR   AlphaFoldDB; B7P1K8; -.
DR   STRING; 6945.B7P1K8; -.
DR   PaxDb; 6945-B7P1K8; -.
DR   EnsemblMetazoa; ISCW015564-RA; ISCW015564-PA; ISCW015564.
DR   KEGG; isc:IscW_ISCW015564; -.
DR   VEuPathDB; VectorBase:ISCI015564; -.
DR   VEuPathDB; VectorBase:ISCP_014868; -.
DR   VEuPathDB; VectorBase:ISCW015564; -.
DR   HOGENOM; CLU_010797_0_0_1; -.
DR   InParanoid; B7P1K8; -.
DR   OMA; IHVVMVE; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0000938; C:GARP complex; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR   GO; GO:0007041; P:lysosomal transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   InterPro; IPR007258; Vps52.
DR   InterPro; IPR048361; Vps52_C.
DR   InterPro; IPR048319; Vps52_CC.
DR   PANTHER; PTHR14190; SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52; 1.
DR   PANTHER; PTHR14190:SF7; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG; 1.
DR   Pfam; PF20655; Vps52_C; 1.
DR   Pfam; PF04129; Vps52_CC; 1.
PE   1: Evidence at protein level;
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B7P1K8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          1..148
FT                   /note="Vps52 coiled-coil"
FT                   /evidence="ECO:0000259|Pfam:PF04129"
FT   DOMAIN          165..483
FT                   /note="Vps52 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20655"
SQ   SEQUENCE   605 AA;  70932 MW;  CAFE67A2A9B22CFF CRC64;
     MENMLKTFQE DLGSISHEIL TLQQQSVSMN VRLKNRQAVR GELSQFVDDI IVPEAMINNI
     LEMPVTEKEF LEQLYVLDHK ISFVKEQSFK DSRSCQDVRD ILEKLKFKAI AKIREYLLQK
     VYSFRKPTTN YQVPQNAMLK HKFCYQFLMT HEREIAREIR DEYVDTMGKI LFSYFKSYTN
     RLMKLQVGRA LGLGHVSLVT LFLTFAFPSS SKNLFSSKPS LKNRSTVFTV GTRNNILTTE
     LESPIIVPHA AQKNDARYPF ESLFRSQQYA LLDNACREYL FVTEFFMCSG SAAQDLFNLI
     MSKTLTMFLK HVELYVQDCY DSIALFLCIH IIHRFQLLMH ERSVPALDRY WESLLQFLYP
     RFEYILRLNI QSIRDCDPQK LGSIDMRPHY ITRRYAEFSA AVVSINENFP SERVASLLAA
     LQGEVENFIL KMAAEFQGRK EQLIFLINNY DMMLSVLLER TKEDSKETES FKELLNARTQ
     EYVEEILAPH FGGMISFVKE CELLQERGQA DVMQREEKKV TMLVRSFNTG WKKAIDDINH
     DIMQTFTNFK NGTNILQAAL MQLIQYYHRF QKVLSQAPFK QLTVRTELLN IHHLMVEVKK
     YKPNF
//