ID   B7P1L4_IXOSC            Unreviewed;      1429 AA.
AC   B7P1L4;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Vacuolar protein-sorting protein, putative {ECO:0000313|EMBL:EEC00486.1};
DE   Flags: Fragment;
GN   ORFNames=IscW_ISCW015570 {ECO:0000313|EMBL:EEC00486.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC00486.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel colony {ECO:0000313|EMBL:EEC00486.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the VPS13 family.
CC       {ECO:0000256|ARBA:ARBA00006545}.
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DR   EMBL; DS616928; EEC00486.1; -; Genomic_DNA.
DR   RefSeq; XP_002433422.1; XM_002433377.1.
DR   STRING; 6945.B7P1L4; -.
DR   PaxDb; 6945-B7P1L4; -.
DR   KEGG; isc:IscW_ISCW015570; -.
DR   VEuPathDB; VectorBase:ISCI015570; -.
DR   VEuPathDB; VectorBase:ISCP_012628; -.
DR   VEuPathDB; VectorBase:ISCP_025989; -.
DR   VEuPathDB; VectorBase:ISCW015570; -.
DR   OMA; ISICARS; -.
DR   PhylomeDB; B7P1L4; -.
DR   InterPro; IPR026847; VPS13.
DR   InterPro; IPR026854; VPS13-like_N.
DR   InterPro; IPR031646; VPS13_extend_chorein.
DR   InterPro; IPR031642; VPS13_mid_RBG.
DR   PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR   PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR   Pfam; PF12624; Chorein_N; 1.
DR   Pfam; PF16908; VPS13_ext_chorein; 1.
DR   Pfam; PF16910; VPS13_mid_rpt; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          2..115
FT                   /note="Chorein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12624"
FT   DOMAIN          132..362
FT                   /note="Vacuolar protein sorting-associated protein 13
FT                   extended chorein"
FT                   /evidence="ECO:0000259|Pfam:PF16908"
FT   DOMAIN          562..639
FT                   /note="VPS13 middle RBG modules"
FT                   /evidence="ECO:0000259|Pfam:PF16910"
FT   REGION          1195..1223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          376..403
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1204..1218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1429
FT                   /evidence="ECO:0000313|EMBL:EEC00486.1"
SQ   SEQUENCE   1429 AA;  161419 MW;  AD7AECD31A3E86D4 CRC64;
     MFEGVVAYLL NKYLGKYIKD LDSENLNVGI FNGTVQLTDL KLKAEALYEL ELPIEVKAGC
     IGKVSVDIPW LSLSSEPVLV HVEDVLILAG PVTDEPYDAE KERLLARARK SRRLELMEEP
     FADNDLDKPR GFFENLIGTI VNNVQVSVQN VHIRYEDTVT SQKFPFACGF VLQSLTAITT
     SSKWKPIQLD STSKTIYKLV KLESFSIYWS SCCSPDGLIR LQLPSANWRN LMRKALQTFS
     VGKDDFEFIL KPISAKVKII FNKSLESKIP KLLVDVLLQD VATQLSRQQY LGMILLKWSF
     ELMEINQRYR KYHPNVPCKG HAREWWKYAY NSVIGEYVRP FSWKAIKEHR RVYRQYKELF
     MKRLQMPNDT EVRVDVQMLE DKLNIANVLM AREEAKLELL RSEPNRAVPR KKEKGWWASW
     FGGGDTEVEP EEEIEVIGER ERSFWSRLTP EEKEKLYEAI EYADASTEVP EHYIAHKINF
     TLANCTLSLV GRGRNHEVLV VTLTQFLTSL ETRPGGGAFK ISARTEGFVV EGASNDHDLV
     TVLSVDKSAN DTSPQYVFAL DFEQNPLDIE ADYGLMLYAE PVEVVYHEHS VSELLTFFSV
     PTVSAEDLRN MAVEQLSSLV TWSRTGLLYA LTHRRVSMAA FDEQSTKDED TKMDPTTEEL
     KLMRHHINRP PDAGGGKHSR SSTQLSIAGS EQYLSASDYS DEEQEVWGRA LDVPGFDDNV
     SASNTVNSLL RFVLGEVALH LSRSSDQLDK PYLMLRLDKL CADVALMEYG PAVQASISGI
     HLVDKLHIGP TGEYLELLSS KANGEMVSML YRKVKASCPE FKSDFHQVEH SLIVDWLNIK
     EPVYRNIIPE SAVKRASYLF VEDSDPPVPP GSTKLSLSLR VREVKVRLCD VDVELADISI
     CARSLMFQSA EKAVQQQVAD FAQKSVMLQL SIDIRAPTIL VPQKSDSPNL VVLSLGDLNM
     ENFFKEVSLG AKPDYVDNIL IRLSSLHMTR REWMLYFRCS QRICEAIVLL DGTTQSQESI
     LEPTKLNLDI KRALTPYHRN ILEYEVRGTM DLIKISIGQK DLGTILAIFR DNFKEKEVIE
     PHKQASTPVS PPVLATPTIT DDPVKKLATF LTTSVDVYKK TNIFFTMEGL HIVLYADGED
     VQRPSVTVDV LIEETSLKVS VPYLLAVLSF VHESLLPPTP SEHELRPVVE GAGAARQHGV
     TAATSRKRLP SDNTSGYHSA VGAPAPEDGA SGLSFSLVLK KPEIVFFADP RDRESEVIVL
     KMDIMLDYCR NLGQHTMTAS VIGLNASSFL WGRKKDTHYL ILKPFNIELN QTLSISDADV
     KLSAKMSDVA VHISAPVLST VVCIMSELLA HIKVTLVYEN YTVKKKVPVL FFQASVDADV
     HDWSKQMYLT AEAKLEALYY SEERSTWEPL IDPVMELENH YRPWELVIK
//