ID B7P2M1_IXOSC Unreviewed; 354 AA.
AC B7P2M1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Zn2+ transporter, putative {ECO:0000313|EMBL:EEC00843.1, ECO:0000313|EnsemblMetazoa:ISCW015929-PA};
DE EC=1.3.1.74 {ECO:0000313|EMBL:EEC00843.1};
GN ORFNames=IscW_ISCW015929 {ECO:0000313|EMBL:EEC00843.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC00843.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC00843.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW015929-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW015929-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBUNIT: Homooligomer. {ECO:0000256|ARBA:ARBA00011182}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
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DR EMBL; ABJB010008513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010711197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS623090; EEC00843.1; -; Genomic_DNA.
DR RefSeq; XP_002402576.1; XM_002402532.1.
DR AlphaFoldDB; B7P2M1; -.
DR STRING; 6945.B7P2M1; -.
DR PaxDb; 6945-B7P2M1; -.
DR EnsemblMetazoa; ISCW015929-RA; ISCW015929-PA; ISCW015929.
DR KEGG; isc:IscW_ISCW015929; -.
DR VEuPathDB; VectorBase:ISCI015929; -.
DR VEuPathDB; VectorBase:ISCP_035607; -.
DR VEuPathDB; VectorBase:ISCW015929; -.
DR HOGENOM; CLU_013430_0_3_1; -.
DR InParanoid; B7P2M1; -.
DR OMA; HAAAFMI; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0032440; F:2-alkenal reductase [NAD(P)+] activity; IEA:UniProtKB-EC.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:1904257; P:zinc ion import into Golgi lumen; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR45755; -; 1.
DR PANTHER; PTHR45755:SF4; ZINC TRANSPORTER 7; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:EEC00843.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P2M1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 135..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 38596 MW; 919C84194FA98247 CRC64;
MRRRGIFFSS CSSTCRSHSS SYSTEYGPTG NLGLISDSFH MFFDCTALLA GLAASVITKW
RANERFSYGY VRAEVLAGFV NGLFLLFIAF FIFSEAVERA IEPPEVKHER LFLISVLGLL
VNFVGIFAFQ HGHSHGGDGH GHSHSHGHSH GSHSHSHSVP SASITATSHS HNHSHGESQG
HSHGNGHGHS HGLDQDCSSE EKLGPGPRSQ IMQGVFLHIL ADTLGSVGVI VSAILMSQFG
WLIADPICSM FIATLIGVSV LPLLRDSIYV LMQRTPKELD AVLPGCYQRV MQLEGVYSVQ
EPHFWTLCSD VFIGTLKIEV AKGADTSYLL SCTHSIFTQA GVKQLYVQID YAPM
//
