ID B7P6N0_IXOSC Unreviewed; 954 AA.
AC B7P6N0;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN ORFNames=IscW_ISCW000464 {ECO:0000313|EMBL:EEC02252.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02252.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02252.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW000464-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000464-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010214485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010464248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010690369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010718218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010769009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010973913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS646990; EEC02252.1; -; Genomic_DNA.
DR RefSeq; XP_002409036.1; XM_002408992.1.
DR AlphaFoldDB; B7P6N0; -.
DR STRING; 6945.B7P6N0; -.
DR PaxDb; 6945-B7P6N0; -.
DR EnsemblMetazoa; ISCW000464-RA; ISCW000464-PA; ISCW000464.
DR KEGG; isc:IscW_ISCW000464; -.
DR VEuPathDB; VectorBase:ISCI000464; -.
DR VEuPathDB; VectorBase:ISCP_006389; -.
DR VEuPathDB; VectorBase:ISCP_010898; -.
DR VEuPathDB; VectorBase:ISCW000464; -.
DR HOGENOM; CLU_003272_0_0_1; -.
DR InParanoid; B7P6N0; -.
DR OMA; FLYNTND; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15440; 7tmB2_latrophilin-like_invertebrate; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR048072; 7tmB2_latrophilin-like.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P6N0};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EEC02252.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 522..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 155..212
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 520..765
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 954 AA; 105198 MW; 697A6B77F291BEF1 CRC64;
MAPTSRHKTC GNADPPRYRT AYACEGSQLH IACDDGHLVQ LIRANYGRFS ISICNEHGTL
DWSVDCMSHR SFRDLPKGTP GGDLVPPLPG TVHAAAPPAV VQADNARTPP PPSPEHVLDI
GFPFRTTTTE ETTEAPSTEA ATQEVSTSLD LLTDFCQPVT VREISWNWTR AGEVAVYPCP
GGARGDARWQ CGVNPVKWLS ERPDLSGCNS FWVGDLERRI HDGVSVVNLA SELAQKTRVK
VLYGGDLLHT TSIVQQLLSK MEDKLDQALD SYQRQQVVEE LMNYVVDFSS NLLEEHQRSS
WGDLPPMEQR AAASSLLEGL ERNAMLLVKS HSANMNYSRL QSNIMVAVRV LGLQSVTDLS
FPDPKMVRGT PWADLGDSIY LPYKTLLESA RNGVVKVAFF SYRQMEAILS APSPPGGDGV
GGNMTRLVNS RVMAAALGRR RVLGLSQPVL VTLRHNKEEN VSDPECVFWD FSKRDWSERG
CWVESSNQTH TTCACNHLTN FAVLMDVRAV QLSYSNEVAL QVITYIGCFI SIICMALTII
TFHFFRSLES DRTVIHKNLC TCLLVAEIVF VAGITQTSQR VVCGVVAGLL HYFFLAAFLW
MFVEGFQLYV MLIEVFDSEK SRLGWYYVLA YGAPAVVVTV AACVDPTSYG TERYCWLRAD
NYFILSFVGP VVAILLANLV FLSIAIYMMC RHASLASSVK NKEQSKMANL RIWIRSATVL
VFLLGLTWAF GLLYLNAESV VMAYLFTFLN SLQGLFIFVF HCLRNDKVRK EYRQLVRQCP
WAPPCVRRED KCPPAERPSY AHSNGTAHSA PSGAALSVRT SCTSTFAHPA PADHIYETID
QEDAFPLSAT VGGGCARFVP IDPGECHIRS RSDASHQSNS SLGCDRRPLI RQRIGGSALS
DAGERPVDPA LVMAVFDGDR VKCTLQGTAP GRLGGKALVT KHPCQPSAHL STDC
//
