ID B7P8X3_IXOSC Unreviewed; 368 AA.
AC B7P8X3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=F-box only protein 6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=IscW_ISCW016774 {ECO:0000313|EMBL:EEC03045.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03045.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03045.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016774-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016774-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010068935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010293468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010680221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010781905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010792546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS660824; EEC03045.1; -; Genomic_DNA.
DR RefSeq; XP_002403295.1; XM_002403251.1.
DR AlphaFoldDB; B7P8X3; -.
DR STRING; 6945.B7P8X3; -.
DR PaxDb; 6945-B7P8X3; -.
DR EnsemblMetazoa; ISCW016774-RA; ISCW016774-PA; ISCW016774.
DR KEGG; isc:IscW_ISCW016774; -.
DR VEuPathDB; VectorBase:ISCI016774; -.
DR VEuPathDB; VectorBase:ISCP_023047; -.
DR VEuPathDB; VectorBase:ISCW016774; -.
DR HOGENOM; CLU_068548_0_0_1; -.
DR InParanoid; B7P8X3; -.
DR OMA; VEICPAM; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR007397; F-box-assoc_dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039752; F-box_only.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12125:SF5; F-BOX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12125; F-BOX ONLY PROTEIN 6-LIKE PROTEIN; 1.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF04300; FBA; 1.
DR SMART; SM01198; FBA; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS51114; FBA; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P8X3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 19..66
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT DOMAIN 165..344
FT /note="FBA"
FT /evidence="ECO:0000259|PROSITE:PS51114"
FT REGION 101..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 368 AA; 41193 MW; 1FDA708938FFD1E2 CRC64;
MRKFFVSRLM GRSAEDVDPF PILELPEQLV EYVLSFVSTD DLVKSCRLVC VQFQRIVDRN
GFWKIKCERD GKVIPSFHLD SLPANYYRAI YVSNPYGRNL LRNGHGDEKG PDNEAPQLPS
KTTKAVAERD CSDVESSGGE HDEMPQAAKP DPASAASSSD GEPESEPPSE DEDYYEDNFF
RRDMFAHWQV TQNHGDGWRV EKTPAGADPL PLANQSCFAT SYGECSKEQV ISLVKEGVVP
EVLDIFKPAI EVSEWYAGRF DCGCMYRLIV ELLDVAKKPV ATFDTGELVT PQWAGRQWQQ
VRHTFDDYPK GVRYVRFAHL GTDTQFWAGH YGAKMAGGMV RIAAEQTNPT STAASRETVD
KTSGAQHS
//
