ID   B7PA41_IXOSC            Unreviewed;      1206 AA.
AC   B7PA41;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   RecName: Full=DNA-dependent protein kinase catalytic subunit CC3 domain-containing protein {ECO:0000259|SMART:SM01344};
GN   ORFNames=IscW_ISCW016752 {ECO:0000313|EMBL:EEC03463.1};
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000313|EMBL:EEC03463.1, ECO:0000313|Proteomes:UP000001555}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC   {ECO:0000313|EMBL:EEC03463.1};
RG   Ixodes scapularis Genome Project Consortium;
RA   Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA   Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA   Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA   Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT   "Annotation of Ixodes scapularis.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ISCW016752-PA}
RP   IDENTIFICATION.
RC   STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016752-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   EMBL; ABJB010086556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010203258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010283430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010334600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010437893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010496199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010516312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010607596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB010920003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABJB011092131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DS669002; EEC03463.1; -; Genomic_DNA.
DR   RefSeq; XP_002406186.1; XM_002406142.1.
DR   AlphaFoldDB; B7PA41; -.
DR   STRING; 6945.B7PA41; -.
DR   PaxDb; 6945-B7PA41; -.
DR   EnsemblMetazoa; ISCW016752-RA; ISCW016752-PA; ISCW016752.
DR   KEGG; isc:IscW_ISCW016752; -.
DR   VEuPathDB; VectorBase:ISCI016752; -.
DR   VEuPathDB; VectorBase:ISCP_027837; -.
DR   VEuPathDB; VectorBase:ISCW016752; -.
DR   HOGENOM; CLU_270246_0_0_1; -.
DR   InParanoid; B7PA41; -.
DR   OMA; HHINENI; -.
DR   Proteomes; UP000001555; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012582; DNAPKcs_CC3.
DR   InterPro; IPR045581; DNAPKcs_CC5.
DR   Pfam; PF08163; DNAPKcs_CC3; 1.
DR   Pfam; PF19704; DNAPKcs_CC5; 2.
DR   SMART; SM01344; NUC194; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT   DOMAIN          71..438
FT                   /note="DNA-dependent protein kinase catalytic subunit CC3"
FT                   /evidence="ECO:0000259|SMART:SM01344"
FT   REGION          760..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          871..900
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1206 AA;  134498 MW;  C65F0C73B0C1D22D CRC64;
     MVAGLERSGS PVLLELLIRV LYRERGSHFL EAEVLLALQR TLTRQVCGET KQQQLIEAAY
     KCGATNQGLL ISARLSLASK LLPLLLKSCS KPALHRFFVD NVTAMVDAVA AKIRHGSESE
     LTSKIVALSC LEVLYSCCLK DDVTGKQSSV NAAFCRSRGI VDVVGNELTK EITKHANSAK
     KEVVRRDVEF ADLWRQLRCA AYRLVVAVVS CTQTESQFYD VFVFQERPEK GEFLWNNLVD
     EKAVYTFPLE REVLFQKSRH VVGVTEGQVP SPSFSGRMAG SLRGSSLAQE ASQYSLSASG
     LPVSRLKVMD LEDDALNGHE CMASVCAVLC RMADLGIIPQ TADEVAGLLP PKWLTFLTNA
     IVGNHTTRNA LCFICRVVVN SAEVLRVHSR HLVPALLNVL AGDKLGSELD AFVIDVAVTV
     LMWASDWSLE NRKTVGNDRD LQGFSELLAQ RCGHERREVL KNNLELLRAW VETWRERLRF
     PADVVLEQLE QCSLDSKDHH AVLLFGIFVS NNLVEFGQSH ASTARFLDKL MLLLPRALAD
     FKVAVLEVLS LCCHQMEQPV GRLQGLGFLE LLAHGDEKMQ TVLLEICTKL VGAATEEDWG
     AILPVVCQLQ GHTSGPCRKL VYDVCMRLYA KYRSKTSAAG LAKQSKHVLL VGLGDPEDSL
     RLSVANFWSQ ETQLPLKARE RLVALLAGMH SPEIEDHFLS SVTFLLLELA SRSPDYGRKL
     FPRPLSDCRF VDYAVTGSWR QRHAAMTPLF AETLSWSQSQ SSTTTSQSTT TSATTDPGPM
     LRATQAELQF TPTQRGTSGA AATTAGSFNW LTQSTLESNL SGAERRRSLS ILSFAPVQEE
     VLLGASQTSQ KSKELGFLRR RFLRDEDKVR LQHIKREVRR KELRGEQERE RRARREAEVT
     LYRSYRLGDL PDIEIPHSAL VAPLQALAQH DQQVAQVLLT SIVKTVVKDG ADLPELCRNF
     ILVCWGLEAP CGCSGKGFSC KWPPELGLYK SLGDYDTVRA TLSCSEDVDA KAKEALQKEA
     QGDYSGARDA YRNLVSSGSI WDDAVLQCCR LLGEWTELQR EVDSRLARSA GNKWDRLWDG
     GYSEEHYLPL YVKSRVKTAL ELGSGEDQFL ESIRQWLEDP ARKRLLEAEC VEELVLLFLL
     QKDMGKADYY VRCFAEQFLE EWSGLSVLTP ALLEGKLESL MVLSDLAEYV KHHTRRASAL
     EHKMDG
//