ID B7PAB4_IXOSC Unreviewed; 497 AA.
AC B7PAB4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 76.
DE SubName: Full=Microspherule protein, putative {ECO:0000313|EMBL:EEC03536.1, ECO:0000313|EnsemblMetazoa:ISCW002145-PA};
GN Name=8026914 {ECO:0000313|EnsemblMetazoa:ISCW002145-PA};
GN ORFNames=IscW_ISCW002145 {ECO:0000313|EMBL:EEC03536.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03536.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03536.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW002145-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW002145-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010762431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS670561; EEC03536.1; -; Genomic_DNA.
DR RefSeq; XP_002406684.1; XM_002406640.1.
DR AlphaFoldDB; B7PAB4; -.
DR STRING; 6945.B7PAB4; -.
DR PaxDb; 6945-B7PAB4; -.
DR EnsemblMetazoa; ISCW002145-RA; ISCW002145-PA; ISCW002145.
DR GeneID; 8026914; -.
DR KEGG; isc:IscW_ISCW002145; -.
DR VEuPathDB; VectorBase:ISCI002145; -.
DR VEuPathDB; VectorBase:ISCP_038168; -.
DR VEuPathDB; VectorBase:ISCW002145; -.
DR HOGENOM; CLU_035858_0_0_1; -.
DR InParanoid; B7PAB4; -.
DR OMA; IQQRWYA; -.
DR OrthoDB; 3519104at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0031011; C:Ino80 complex; IEA:InterPro.
DR GO; GO:0071339; C:MLL1 complex; IEA:InterPro.
DR GO; GO:0044545; C:NSL complex; IBA:GO_Central.
DR GO; GO:0002151; F:G-quadruplex RNA binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd22687; FHA_MCRS1; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR037912; MCRS1.
DR InterPro; IPR025999; MCRS_N.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR13233; MICROSPHERULE PROTEIN 1; 1.
DR PANTHER; PTHR13233:SF0; MICROSPHERULE PROTEIN 1; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF13325; MCRS_N; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PAB4};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 401..457
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 54796 MW; BB5AB0089CA96D8B CRC64;
MSSNLILGPV ASDNSQDVSE VSQAPESPPT AMGHLNFSNS DSESVPRPPS TAVHPGMKVN
SYLSEHLQKR RSSSRSIKRK KFDDELVESS LIKTSRARPL GGPLSSSLTA GVGPMAASSS
LTSVVASFSD SSQVESVASL YSERKKSSKS TPKRVKKSSK SAQAVVAKDL GRWKPHDDYA
LILAVQQTTD LEAVFRAVKF SCNFTLQEIR ERWYALLYDP AISKMAVASM KQLHPDVLAG
IQAKALFSEE EELLLGTIPS TAQPTLEDFQ ELLEKHVDVF LAAHTAKALQ NHWTLMKQYY
LLPDQTVPPR SKGEDTLSFS DAEEELERDP LGSPKDEALE HELFLMDRGV KQEIRQLENE
LPKWQVLVDS VTGVTPADFD NQTLAVLRGR LVRYLMRSKE ITIGRATKDS AIDVDLSLEG
PAWKVSRRQG VVKLRNTGEF IIANEGKRPI YIDGKPVLAG DKHKLNNNSV VEIAGLRFIF
LVNQDLISVI CSPQSCA
//
