ID B7PAE8_IXOSC Unreviewed; 498 AA.
AC B7PAE8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=tRNA (cytosine(34)-C(5))-methyltransferase {ECO:0000256|ARBA:ARBA00012629};
DE EC=2.1.1.203 {ECO:0000256|ARBA:ARBA00012629};
GN ORFNames=IscW_ISCW003251 {ECO:0000313|EMBL:EEC03570.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03570.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03570.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW003251-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW003251-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; ABJB010151619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010807220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010976018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010993214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011021751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011072482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS671064; EEC03570.1; -; Genomic_DNA.
DR RefSeq; XP_002406816.1; XM_002406772.1.
DR AlphaFoldDB; B7PAE8; -.
DR STRING; 6945.B7PAE8; -.
DR PaxDb; 6945-B7PAE8; -.
DR EnsemblMetazoa; ISCW003251-RA; ISCW003251-PA; ISCW003251.
DR KEGG; isc:IscW_ISCW003251; -.
DR VEuPathDB; VectorBase:ISCI003251; -.
DR VEuPathDB; VectorBase:ISCP_032074; -.
DR VEuPathDB; VectorBase:ISCW003251; -.
DR HOGENOM; CLU_005316_4_3_1; -.
DR InParanoid; B7PAE8; -.
DR OMA; TQRKHFQ; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016428; F:tRNA (cytidine-5-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030488; P:tRNA methylation; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR023270; RCMT_NCL1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22808:SF1; RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR PRINTS; PR02011; RCMTNCL1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 1: Evidence at protein level;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PAE8};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 1..247
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 254..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 139
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 2..8
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 32
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 59
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 86
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 498 AA; 56446 MW; 8B5A498C06218DF6 CRC64;
MCAAPGSKTA QLMEMLHGRV SNIPTGVVVA NDVDNKRCYM LVHQAKRLHS TCCLVTNHDA
AAMPNIYLTN KDGTQEVVKY DRILCDVPCS GDGTLRKNVD LWRKWNVANG NSIHGLQVRI
ARRGLELLAE GGILVYSTCS LNPLEDEAVV ASLLLQCEGA VELVDVSGRL PGLVSRPGLT
TWKVSSKDMA VYTSFDQVPE MYHTQIRAQM FPPSPEVAAQ LKLERCVRIL PHQQDTGGFF
VAVLKKTGSK LPWESQNRAK PTTLAEENGE EENQTVRQEK IVAPRKKRRI QGYKEDPFVF
LTEDDEIWKT VRDFYKVDES FPNTQLLGRC QQENKRTIYL VSETVKNIIE TNGDKLKVIN
TGVRVFCRCE GKEEMACNFR VCQEGLPTVL PFLGSRKLRM SKEDLYVMLT EEYPLETQFS
PELQAQLKDL GRAQYPTPEE FELVLAGRRG KATLRCYVAK QERVHYLRVC GYDVSEYEKR
DKKKKVDSTK AEVLRKCL
//