ID B7PAG5_IXOSC Unreviewed; 236 AA.
AC B7PAG5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Chloride channel, putative {ECO:0000313|EMBL:EEC03587.1, ECO:0000313|EnsemblMetazoa:ISCW001866-PA};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW001866 {ECO:0000313|EMBL:EEC03587.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03587.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03587.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW001866-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW001866-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ABJB010038561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010075537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010949344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS671188; EEC03587.1; -; Genomic_DNA.
DR RefSeq; XP_002406840.1; XM_002406796.1.
DR AlphaFoldDB; B7PAG5; -.
DR STRING; 6945.B7PAG5; -.
DR PaxDb; 6945-B7PAG5; -.
DR EnsemblMetazoa; ISCW001866-RA; ISCW001866-PA; ISCW001866.
DR KEGG; isc:IscW_ISCW001866; -.
DR VEuPathDB; VectorBase:ISCI001866; -.
DR VEuPathDB; VectorBase:ISCP_020780; -.
DR VEuPathDB; VectorBase:ISCW001866; -.
DR HOGENOM; CLU_062945_1_0_1; -.
DR InParanoid; B7PAG5; -.
DR OMA; MCIETIC; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PAG5};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC03587.1"
FT NON_TER 236
FT /evidence="ECO:0000313|EMBL:EEC03587.1"
SQ SEQUENCE 236 AA; 25470 MW; 35135B2A1C43149F CRC64;
FQSLDYDPCE NAPYMDDQRS TTFSQIRKTN QTRWLVILVI GILTAVTACL IDMCIETICD
YKFDLLQHWM NQCIRDDCII VPYLAWVGMN AGAVLAGSAL VAYVAPVAAA SGIPVIKCYL
NGVKVPEVVR FKTLLVKAVG VVLSVVGGLA VGKEGPMIHC GSVIAAGVSQ GKSTTFRKDL
RVFKDFREDH EKRDFVSAGA AAGVAAAFGA PVGGVLFSLE EGASFWNQSL TWRIVS
//
