ID B7PAZ4_IXOSC Unreviewed; 280 AA.
AC B7PAZ4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Neurotransmitter gated ion channel, putative {ECO:0000313|EMBL:EEC03766.1, ECO:0000313|EnsemblMetazoa:ISCW017156-PA};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW017156 {ECO:0000313|EMBL:EEC03766.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03766.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03766.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW017156-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW017156-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; ABJB010014710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010253444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010346371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010688575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010740458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010866145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010908549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011024885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS673969; EEC03766.1; -; Genomic_DNA.
DR RefSeq; XP_002407499.1; XM_002407455.1.
DR AlphaFoldDB; B7PAZ4; -.
DR STRING; 6945.B7PAZ4; -.
DR PaxDb; 6945-B7PAZ4; -.
DR EnsemblMetazoa; ISCW017156-RA; ISCW017156-PA; ISCW017156.
DR KEGG; isc:IscW_ISCW017156; -.
DR VEuPathDB; VectorBase:ISCI017156; -.
DR VEuPathDB; VectorBase:ISCP_032689; -.
DR VEuPathDB; VectorBase:ISCW017156; -.
DR HOGENOM; CLU_995948_0_0_1; -.
DR InParanoid; B7PAZ4; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF843; IP12572P-RELATED; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transport {ECO:0000256|RuleBase:RU000687}.
FT DOMAIN 56..193
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT REGION 206..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC03766.1"
SQ SEQUENCE 280 AA; 32071 MW; 0C23784FAF1912FE CRC64;
PRNNSWRNAR PIFHYSGVLG QIARYCRIAR IAARASLKVA TDLRSPTTAM TIPFADYDMD
MYLRLAWKDP RLSMRRFGIN RTLTLNGQHL LSRMWKPDLF FVNAKEVRTH SVTIPNELLQ
LSPDGDILIS IRLTMKLSCL MLFHNFPFDK QKCYALARPY AHPLNQIMLV WREKEPVFLE
LPIEMQDFDL MAMSYDDYTE EIETVPAHGT RGTAGRSRDK PASAPHSHVG RSSSSVRSPG
FRPVNVQVFG GDDNVLDASC FFSVGDSLRR CAFMLRLRRS
//
