ID B7PC28_IXOSC Unreviewed; 1700 AA.
AC B7PC28;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=ABC transporter, putative {ECO:0000313|EMBL:EEC04150.1, ECO:0000313|EnsemblMetazoa:ISCW016982-PA};
DE EC=3.6.3.30 {ECO:0000313|EMBL:EEC04150.1};
DE EC=3.6.3.40 {ECO:0000313|EMBL:EEC04150.1};
GN ORFNames=IscW_ISCW016982 {ECO:0000313|EMBL:EEC04150.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC04150.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC04150.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016982-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016982-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ABJB010059355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010565584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010730202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010905682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011028607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS681185; EEC04150.1; -; Genomic_DNA.
DR RefSeq; XP_002409253.1; XM_002409209.1.
DR PaxDb; 6945-B7PC28; -.
DR EnsemblMetazoa; ISCW016982-RA; ISCW016982-PA; ISCW016982.
DR KEGG; isc:IscW_ISCW016982; -.
DR VEuPathDB; VectorBase:ISCI016982; -.
DR VEuPathDB; VectorBase:ISCP_007562; -.
DR VEuPathDB; VectorBase:ISCP_034394; -.
DR VEuPathDB; VectorBase:ISCW016982; -.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; B7PC28; -.
DR OMA; NFGMSIS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:EEC04150.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 260..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1177..1201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1208..1229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1306..1327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 532..761
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1383..1613
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 494..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1700 AA; 189801 MW; E1C7926BB1C658D4 CRC64;
MDVVPPQLSL LIWKCYVTSI KRRKLTFALE VLVPGLLALT LVYARLHVTF ETVHNVTLFE
HLSINRLPLR YRLPPPSASK WILYYAPNTE LVNRLLDNVA NDAVPQLEAR GFETEEAMVA
HYTAEMAHRD SVLGGIVFPD FENNATQMFV DRVRFKVRLK AAPRMKLSNS EPLQSWSTDS
NFPVLQVFSP RHPKNKDDGS PGYFAEGFLY LQQEVFQEVL VHMVNQGNFN VSMPVPTTVL
LQRFPLPPYT TDPFFFIIQY FLPIIVLLCF TSPSLSVIRH VSTEKESGMR DFLQMMGINP
WLNYIAWFFV TLMAMTVSSG VLVFTTMTPL TGNGPVIRNS NPLVILLLFV VYSTSTINFA
FLVGSLFNSA NTSVAGLFTA YTASFFPFLL FFSMNNTHTT TATILACLLC NTALPLGVTM
TAVLEAGNEG AQWNNIALNP NPGLGLSLFS IINMLIFDTV LYAVLVWYIE GSHMNRLVDR
QPWTLEKRTS RYQLDPQRQV SSHSKPGQPE TRPKDATSVC FEEFSLKAIP GVELVNLTKV
YNKVPVVNNV SFKAFRGQIT ALLGHNGAGK TTTIRMITGQ LASTKGLVLI GGHNVKTQSQ
AAHEDMGICP QTDIHFKDMT VYEHLLFFSE LKRVPSSEIE QQLCKLLSLL KMSQKRAVLA
RHLSGGYRRK LSIGIALVGN SKVVILDEPT AGMDPAARRE IWDLLILEKA NRTILLTTHA
MEEADAIGDR IAIMANGVIQ CCGTSFFLKK NLGAGYHMVI VKNPVCNVRT LLEVVAAFAP
SAEMESNVGT ELSLRISRFD QPFFKHLFSH LEDNKEKLGI SSFGVSVTTL EEVFLRRSKR
GCVHRKHVSI HIPLEIRHRR TLVRLTKSDS QLIGILNSFM PSSGSSDESG EKSPTNTGFR
LFVQQTWALL TMNMLNSVRN VQLTASQLLV PLAVLSFTLT WIDLLPKVYI PSARLLDINR
IHWSTVPYSF RGNKSRSLIE AFKNQLDSYR VMALPVEDNM NGYLLDQTLG DSSDFMLNTL
IAMDSMDEAT AGRVVHLFFN NQMFHTPAIA LMAYQRALLH ETLANSSVKL EIINHPFPRV
VEEKANKLLT MHRESFQIGH QAVFGTSFLV SSFAIFLVID HVSGSRHLQR ISGLNMAAYW
IANLTWSMFI YLLSTAIVIA TLIFSGVPGF ADGKEQVVIF LVFFYYGCSA LPLVAAASFI
FHSHSSACVR IGTVNFAIGL SSLVLVALLE WQNEKHFMDL ATSIDSVVTA LAPMYGLGRA
ISTLYRNTHF NLVCNDALVE FSSDYCQGLE CINWQPDIFD WGSLHISWAI LSFGVHAILG
TLVLWMFEKN ASYFVERLSI SRIQTTLHSD QLETEVLEDD NVAEERCRII TTPIEELSAK
DILVMRELCR SYGNTKAVND LSLGIRRGEC FGLLGINGAG KTTTFKMLTG TIKVTAGDAF
VDGYSVVHKP REVSKRIGYC PQHDALPEFL TGREVLTLYA RIRGIPESHI PLVCTALAKL
FYFHMHLDKT LRTYSGGNKR KVSTAVAFVG SPYLVILDEP STGMDPVAKR CLWRTLVGLM
GSGRSIILTS HSMEECEAMC SSLVIMVNGR FCCLGSPQHL KNKFGSGYSI MIKVSGARIL
MGSPISLRCS QARLPNIDLI GVHDGLLEYH LPATSMTWAE IFDIMDQVKS VFNVVDYSVA
QLTLEQVFLH FAMLQREAQT
//
