ID B7PC94_IXOSC Unreviewed; 431 AA.
AC B7PC94;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=tryptophan--tRNA ligase {ECO:0000256|ARBA:ARBA00013161};
DE EC=6.1.1.2 {ECO:0000256|ARBA:ARBA00013161};
DE AltName: Full=Tryptophanyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030268};
DE Flags: Fragment;
GN Name=8027771 {ECO:0000313|EnsemblMetazoa:ISCW016908-PA};
GN ORFNames=IscW_ISCW016908 {ECO:0000313|EMBL:EEC04216.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC04216.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC04216.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016908-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016908-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363036}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010421942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010483326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010790312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010819758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011137968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS682322; EEC04216.1; -; Genomic_DNA.
DR RefSeq; XP_002409503.1; XM_002409459.1.
DR AlphaFoldDB; B7PC94; -.
DR STRING; 6945.B7PC94; -.
DR PaxDb; 6945-B7PC94; -.
DR EnsemblMetazoa; ISCW016908-RA; ISCW016908-PA; ISCW016908.
DR GeneID; 8027771; -.
DR KEGG; isc:IscW_ISCW016908; -.
DR VEuPathDB; VectorBase:ISCI016908; -.
DR VEuPathDB; VectorBase:ISCP_037329; -.
DR VEuPathDB; VectorBase:ISCW016908; -.
DR HOGENOM; CLU_032621_0_1_1; -.
DR InParanoid; B7PC94; -.
DR OMA; SIYHRFM; -.
DR OrthoDB; 540846at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004830; F:tryptophan-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IBA:GO_Central.
DR CDD; cd00806; TrpRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR002306; Trp-tRNA-ligase.
DR NCBIfam; TIGR00233; trpS; 1.
DR PANTHER; PTHR10055:SF1; TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10055; TRYPTOPHANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01039; TRNASYNTHTRP.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 1: Evidence at protein level;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363036};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363036};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363036};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363036};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363036};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PC94};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC04216.1"
SQ SEQUENCE 431 AA; 48567 MW; 2D5D48776A2CD9FA CRC64;
LANRYTVTRA AGGRIEMSAS LEQMSALSLE DGGDHASTEP DCDVVNPWNV VSASTTGIDY
DKLIVKFGSS KMTQDLVDRV EALTGKKAHH FLRRGIFVSH REFNEILNIY EQKKPFYLYT
GRGPSSDALH VGHLIPFIFT KWLQDTFDVP LVIQLTDDEK FLWKDMTVEE AEKMAHENIR
DIVACGFDPA NTFIFTDFKY TGQCPEFYKN IVRIRRSVTF NQVKGIFGFG DSDCIGKIGF
PAVQAAPSFS SSFPFIFGEQ SRVPCLIPCG IDQDPYFRMT RDVAPRLGFP KPALLHSVFF
PALQGAQSKM SASDPNSSIF LTDTPAQIKN KINKYAFSGG GATVEEHKEK GGNCDVDISY
QYLRFFLEDD ERLEKIRQDY TSGELLTGFL KKELIEVLQK RIAAHQAARK LVTDEVIAKF
TTPRPLQFKR Q
//
