ID B7PCH9_IXOSC Unreviewed; 154 AA.
AC B7PCH9;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Adenosine 5'-monophosphoramidase HINT3 {ECO:0000256|ARBA:ARBA00039802};
DE AltName: Full=Histidine triad nucleotide-binding protein 3 {ECO:0000256|ARBA:ARBA00042361};
DE Flags: Fragment;
GN Name=8027881 {ECO:0000313|EnsemblMetazoa:ISCW016833-PA};
GN ORFNames=IscW_ISCW016833 {ECO:0000313|EMBL:EEC04301.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC04301.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC04301.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016833-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016833-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine 5'-phosphoramidate + H2O = AMP + NH4(+);
CC Xref=Rhea:RHEA:67916, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57890, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00024472};
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DR EMBL; ABJB010216263; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010280168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010300560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010338874; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010614678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS684069; EEC04301.1; -; Genomic_DNA.
DR RefSeq; XP_002409872.1; XM_002409828.1.
DR AlphaFoldDB; B7PCH9; -.
DR STRING; 6945.B7PCH9; -.
DR PaxDb; 6945-B7PCH9; -.
DR EnsemblMetazoa; ISCW016833-RA; ISCW016833-PA; ISCW016833.
DR KEGG; isc:IscW_ISCW016833; -.
DR VEuPathDB; VectorBase:ISCI016833; -.
DR VEuPathDB; VectorBase:ISCP_012397; -.
DR VEuPathDB; VectorBase:ISCW016833; -.
DR HOGENOM; CLU_056776_4_2_1; -.
DR InParanoid; B7PCH9; -.
DR OMA; FCKIVNN; -.
DR OrthoDB; 2782915at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR12486:SF5; ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3; 1.
DR PANTHER; PTHR12486; APRATAXIN-RELATED; 1.
DR Pfam; PF11969; DcpS_C; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 1: Evidence at protein level;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PCH9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 16..123
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT MOTIF 108..112
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC04301.1"
SQ SEQUENCE 154 AA; 17154 MW; F0F7EC2648E5EF9C CRC64;
LFSNAPPGSE QGTPCLFCNI ASAKDPNTTL LYQDEEYVVF RDIHPASTHH YLVVPKMHIR
SVKGLTPADI PLVRRLIDIG QQVLLEKGGT LDSLRMGFHW PPFTSINHLH LHIISPMEQM
STLSKVIYMP GSAWFCPVDD AIAYIERTGT SPDA
//
