ID B7PF95_IXOSC Unreviewed; 302 AA.
AC B7PF95;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 76.
DE SubName: Full=X-linked inhibitor of apotosis protein, putative {ECO:0000313|EMBL:EEC05267.1, ECO:0000313|EnsemblMetazoa:ISCW004187-PA};
GN ORFNames=IscW_ISCW004187 {ECO:0000313|EMBL:EEC05267.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC05267.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC05267.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW004187-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW004187-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010062451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010272891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010704237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS700558; EEC05267.1; -; Genomic_DNA.
DR RefSeq; XP_002433867.1; XM_002433822.1.
DR AlphaFoldDB; B7PF95; -.
DR STRING; 6945.B7PF95; -.
DR PaxDb; 6945-B7PF95; -.
DR EnsemblMetazoa; ISCW004187-RA; ISCW004187-PA; ISCW004187.
DR KEGG; isc:IscW_ISCW004187; -.
DR VEuPathDB; VectorBase:ISCI004187; -.
DR VEuPathDB; VectorBase:ISCP_000856; -.
DR VEuPathDB; VectorBase:ISCW004187; -.
DR HOGENOM; CLU_016347_2_0_1; -.
DR InParanoid; B7PF95; -.
DR OMA; IHDEHEV; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR CDD; cd00022; BIR; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10044:SF139; DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2; 1.
DR PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR Pfam; PF00653; BIR; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00238; BIR; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PF95};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT REGION 17..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 33277 MW; 9C3660E8988136F3 CRC64;
MVVISMAIGN IAYQPPPKPV DVVDGDQEPR DPGGAPQSNG QPFAESLRAV DRTAPMFPDY
KTLVSRVQSF GDEYVQKFKG DPETLAKAGL FYNGFMECDR AVCFQCGGGL YQWDDGDSPF
EEHARWYPDC PFVRLSLGDA EVQRIQDEHL QALQEAATDH NGGDANDSAA DDQVEEAVTR
YLDGEASRRS FFQEFGITAA TVRNAVKLLI SRGQQDRIHD EHEVDAAIKE TVSLQKSSIS
AESVAKGQES TDSRCLLCHK NDRQVIFSPC FHLVACESCS ATLQVCSVCK KPIKENIKAF
LS
//
