ID B7PFU2_IXOSC Unreviewed; 398 AA.
AC B7PFU2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 62.
DE RecName: Full=Proline-rich AKT1 substrate 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=IscW_ISCW017627 {ECO:0000313|EMBL:EEC05464.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC05464.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC05464.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW017627-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW017627-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010240118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010260191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010750753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011069304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS704057; EEC05464.1; -; Genomic_DNA.
DR RefSeq; XP_002434064.1; XM_002434019.1.
DR AlphaFoldDB; B7PFU2; -.
DR STRING; 6945.B7PFU2; -.
DR PaxDb; 6945-B7PFU2; -.
DR EnsemblMetazoa; ISCW017627-RA; ISCW017627-PA; ISCW017627.
DR KEGG; isc:IscW_ISCW017627; -.
DR VEuPathDB; VectorBase:ISCI017627; -.
DR VEuPathDB; VectorBase:ISCP_006867; -.
DR VEuPathDB; VectorBase:ISCW017627; -.
DR HOGENOM; CLU_050595_0_0_1; -.
DR InParanoid; B7PFU2; -.
DR OMA; FRERAHN; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IBA:GO_Central.
DR GO; GO:0048011; P:neurotrophin TRK receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR026682; AKT1S1.
DR PANTHER; PTHR21844; AKT1 SUBSTRATE 1 PROTEIN; 1.
DR PANTHER; PTHR21844:SF2; PROLINE-RICH AKT1 SUBSTRATE 1; 1.
DR Pfam; PF15798; PRAS; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PFU2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT REGION 231..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..184
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 231..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 44379 MW; A70FDB21040F5FBC CRC64;
MAVLACQCLN WSVHCQESRV EACDPRHLDL SEEERTDRFF ASAVARVKLG IGGISQKHPF
LSTVRHVGQW SVHSCRGCRQ DVYAEASGRM LLHAGLESGQ ERMDTLRALE RYSPCFKIVL
PQPGDDDDDS RGVSGARLQV EDSKLDANLK VVQEIATRFV RQEMEAMEAR IRHFQEQQSR
TLEQLKARTA VDRDALCELL TQASRRELKN TLAEALDEEV TQRIPTVRSN AVATTQNRGG
LPKTTDNNRD AGITFQKGTA RRQGVRRPAR PGPQLLLSQS VDTGQIFHLD GFEDDDNSAP
FPPASSEEEL DTDDSSMADE YQPAGQTQCA YSLPVDMPTW RTPRDSQNDL DELVGAVDHE
KIGEDIEALA RSVCDGTEMF GDLPRPRLNA GDHRSRPL
//
