ID B7PFW5_IXOSC Unreviewed; 385 AA.
AC B7PFW5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Endothelial transcription factor GATA-2, putative {ECO:0000313|EMBL:EEC05487.1, ECO:0000313|EnsemblMetazoa:ISCW004992-PA};
GN ORFNames=IscW_ISCW004992 {ECO:0000313|EMBL:EEC05487.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC05487.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC05487.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW004992-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW004992-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ABJB010004826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010094199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010164237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010517088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010878681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011119738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS704151; EEC05487.1; -; Genomic_DNA.
DR RefSeq; XP_002434087.1; XM_002434042.1.
DR AlphaFoldDB; B7PFW5; -.
DR STRING; 6945.B7PFW5; -.
DR PaxDb; 6945-B7PFW5; -.
DR EnsemblMetazoa; ISCW004992-RA; ISCW004992-PA; ISCW004992.
DR KEGG; isc:IscW_ISCW004992; -.
DR VEuPathDB; VectorBase:ISCI004992; -.
DR VEuPathDB; VectorBase:ISCP_033877; -.
DR VEuPathDB; VectorBase:ISCW004992; -.
DR HOGENOM; CLU_027524_3_0_1; -.
DR InParanoid; B7PFW5; -.
DR OMA; GYPCSSN; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00202; ZnF_GATA; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2.
DR InterPro; IPR016374; TF_GATA-2/3.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071:SF335; GATA-BINDING FACTOR C; 1.
DR PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1.
DR Pfam; PF00320; GATA; 2.
DR PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00094}.
FT DOMAIN 174..228
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT DOMAIN 228..281
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 47..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..82
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 40498 MW; 75D0D8EB9680C02B CRC64;
MWDPRVPGGQ VCRPHFHSAL HPWISDPAKA AAAAAMVPHH GPASWCSPFA GKPQPSPPTA
PSHSSPHLFS FPPTPPKDAT PDPAAAEAPG YACDGDHKPG GMLTPLAASS ACGKREGTFP
ASSPPYPHYV PHPGSELAGY HGFHAGPLQL AKAPLPPPAG YGQAAKPRTK GRSSAEGREC
VNCGATSTPL WRRDGTGHYL CNACGLYHKM NGQNRPLIKP KRRLSAARRA GTSCANCKTT
TTTLWRRNQN GEPVCNACGL YFKLHNVNRP LTMKKEGIQT RNRKLSSKSK KKKGLTMSLP
DCIKPLDKGF SSFSPAGHQF ASSMSMTMNH YMHQGNMNMP ISMGGTFVTS QHMGSAAGLS
GLGLGPSASA GLGLAASNSM VGAMA
//
