ID B7PH10_IXOSC Unreviewed; 240 AA.
AC B7PH10;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW005053 {ECO:0000313|EMBL:EEC05882.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC05882.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC05882.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW005053-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW005053-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; ABJB010231613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011112419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS710151; EEC05882.1; -; Genomic_DNA.
DR RefSeq; XP_002401787.1; XM_002401743.1.
DR AlphaFoldDB; B7PH10; -.
DR STRING; 6945.B7PH10; -.
DR PaxDb; 6945-B7PH10; -.
DR EnsemblMetazoa; ISCW005053-RA; ISCW005053-PA; ISCW005053.
DR KEGG; isc:IscW_ISCW005053; -.
DR VEuPathDB; VectorBase:ISCI005053; -.
DR VEuPathDB; VectorBase:ISCP_036300; -.
DR VEuPathDB; VectorBase:ISCW005053; -.
DR HOGENOM; CLU_033039_3_0_1; -.
DR InParanoid; B7PH10; -.
DR OMA; CREPRTC; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF70; PROTEIN WNT-16; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT DOMAIN 68..110
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC05882.1"
SQ SEQUENCE 240 AA; 25981 MW; 3706025103694968 CRC64;
AGSPETAFVY ALHSAGVAHS VARACAAGRL RECSCGPGST TSSSAGPSGV SQQDAWRWGG
CSDDVRAGLR GRRAAAAARA AGRTLRRAAN LHNLKAGRLA LSGKVRLRCR CHGVSGSCGL
RSCWRSLGPL AAVGRVLRDK YRRSVPLLQR GSRANGPRPR ASDLVHVRPS ADVCRPGPEG
VPVSRGRPCR EPRTCDRLCC GRGFETRTVR RLQRCRCRFH WCCYVTCDVC ETRMKTYSCR
//
