ID B7PH24_IXOSC Unreviewed; 703 AA.
AC B7PH24;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 88.
DE SubName: Full=Serine protease inhibitor, putative {ECO:0000313|EMBL:EEC05896.1, ECO:0000313|EnsemblMetazoa:ISCW005088-PA};
DE EC=2.7.11.1 {ECO:0000313|EMBL:EEC05896.1};
GN ORFNames=IscW_ISCW005088 {ECO:0000313|EMBL:EEC05896.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC05896.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC05896.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW005088-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW005088-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR EMBL; ABJB010166940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010405502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010863599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010888081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010938637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS710681; EEC05896.1; -; Genomic_DNA.
DR RefSeq; XP_002401986.1; XM_002401942.1.
DR AlphaFoldDB; B7PH24; -.
DR PaxDb; 6945-B7PH24; -.
DR EnsemblMetazoa; ISCW005088-RA; ISCW005088-PA; ISCW005088.
DR KEGG; isc:IscW_ISCW005088; -.
DR VEuPathDB; VectorBase:ISCI005088; -.
DR VEuPathDB; VectorBase:ISCP_020568; -.
DR VEuPathDB; VectorBase:ISCW005088; -.
DR HOGENOM; CLU_011341_0_0_1; -.
DR InParanoid; B7PH24; -.
DR OMA; FTMISAK; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd19577; serpinJ_IRS-2-like; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 2.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 2.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF211; ACCESSORY GLAND PROTEIN ACP76A-RELATED; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 2.
DR SMART; SM00093; SERPIN; 2.
DR SUPFAM; SSF56574; Serpins; 2.
DR PROSITE; PS00284; SERPIN; 1.
PE 1: Evidence at protein level;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PH24};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:EEC05896.1}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..703
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010826131"
FT DOMAIN 39..333
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT DOMAIN 336..703
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 703 AA; 77643 MW; C06F6978A606ED42 CRC64;
MWFPALLALA CSCCVIAEPN ELEDPSYGGV VRASNDFGLT LYTTLANGSD GNLFFSPWSL
SRVLTMVLLG ARNETASELS RALSLDSIGD ADVVLAAQRR QAQQLGKSDE LATTSMALTR
VGDPVSAEYL ASLDRYLDDG GVMQVDFSRA DELLNRVNGE VSRLTGGRIR DALRRSPDPL
SKLLLLNAVH FKGVWAKAFS PNDTFDGVFR GATKNTPVRM MAAKGKFRLS YDGAAYVLEL
PYTGDSSLVI VLPRNRLQRD LQDLEHRLQE LLMAPPAELR SLELELPQLY ENSVLRRRHN
SRDAMKRCTL VALLLAVAAA RADRDAVSRA SNDLGLALYR KLAEVDSKGG NVFLSPVSVA
AILGMVQLGA RGRTRQELDE ALAGGSNKLG KVSGDDLAAG FGQLLKDLRA EKGYDLRIAS
AVFIASGLPI FERYKKDLDK HFASGIYSAD FAGNGREAAQ DVNSWVRDMT EDRIPEILER
PLPPSAPLLV LNAVYFRGLW LNPFKPNETR KEDFYNRGTR AVPVDMMHVK EELVYAYSDA
LDADILELPY QGDRVVMVLV LPRKRDGLPD LERRFALEPI REALAGAVQR RVDVRLPKFQ
LQLSYSLRSV LQSLGVREAF NAQGANLSGI SGSRRLSLDE VLHKALLDVD EQGTEAVALS
SGIVRHSRPP EEEVQFKADH PFIFFIEDVR SQTLLFLGRL QEV
//
