ID B7PHG5_IXOSC Unreviewed; 766 AA.
AC B7PHG5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Carnitine palmitoyltransferase I, putative {ECO:0000313|EMBL:EEC06037.1};
DE EC=2.3.1.21 {ECO:0000313|EMBL:EEC06037.1};
GN ORFNames=IscW_ISCW018288 {ECO:0000313|EMBL:EEC06037.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06037.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06037.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018288-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018288-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR EMBL; ABJB010818082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011006329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS712856; EEC06037.1; -; Genomic_DNA.
DR RefSeq; XP_002402791.1; XM_002402747.1.
DR AlphaFoldDB; B7PHG5; -.
DR STRING; 6945.B7PHG5; -.
DR PaxDb; 6945-B7PHG5; -.
DR EnsemblMetazoa; ISCW018288-RA; ISCW018288-PA; ISCW018288.
DR KEGG; isc:IscW_ISCW018288; -.
DR VEuPathDB; VectorBase:ISCI018288; -.
DR VEuPathDB; VectorBase:ISCP_022114; -.
DR VEuPathDB; VectorBase:ISCW018288; -.
DR HOGENOM; CLU_013513_2_1_1; -.
DR InParanoid; B7PHG5; -.
DR OMA; NTEHSWG; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0009437; P:carnitine metabolic process; IBA:GO_Central.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:0006631; P:fatty acid metabolic process; IBA:GO_Central.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 1: Evidence at protein level;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PHG5};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..46
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 178..756
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 473
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 766 AA; 87298 MW; B8EC2F058C071EB0 CRC64;
MAEAHQAVAF SFTVTHEGVN INYDREVLLL VWQSGLRSWK KRVARFLTNL YNGVYPSSYR
SLYFLLSVVT GLSLLEQDGG LVEQIASLVS MEKAPSAAPS ILPRLATSGA VSVVLWVVWS
LAQRYALKGL FMYKGWMYES RGSGSKVSLT TRLWFCGVRL LKGKNPLLFS YQSTLPKLPL
PSLDDTMERY LRSVRPLLDD ANYARMEGLA KDFRHGIAQK LQRYLWLKSW WSSNYVSDWW
EEYVYLRGRS PIMVNSNFYA IDAILVKLTS NQAARAANLV YASFLFRRGI DSQQMTPIMV
QNTVPLCSRQ YERIFNTTRV PGVETDQLVH YQDSQHVAVY HRGRFFKLPV YHKHRLLQPC
DLQRQLEHIL SNESAPQVGE ERLAALTAGE RSAWAKLREA HFRKGLNRIS LDAIEKAAFV
LVLDEDEYDP KDPGQLNHYA RSLLHGRGHD RWFDKSFNLI VGSNARVGFN AEHSWADAPI
MGHYWEFVLA QDFFILKYDE AGNTLGFSSL ELPNPVRLRW DLSPELVSHI EASSLAAVAL
LEDVDLHLLT HTAYGKGFMK KCRCSPDAFL QMALQLAYYR DAGRFSLTYE ASMTRLFREG
RTETVRPVTC ESRTWVLAML EPNATVQERR QKLAIACARH QKGARDAMCG KGIDRHLFCL
YVVSKYLEVD SPFLREVLSE PWRLSTSQTP HNQTSLLDLS KFPDFISAGG GFGPVADDGY
GVSYLIAGED HLFFHVSSKR SSPETDSLRF AKHIEQSLKD MRALFE
//
