ID B7PHP3_IXOSC Unreviewed; 689 AA.
AC B7PHP3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 08-NOV-2023, entry version 70.
DE SubName: Full=Ankyrin repeat-containing protein {ECO:0000313|EMBL:EEC06115.1, ECO:0000313|EnsemblMetazoa:ISCW018235-PA};
GN ORFNames=IscW_ISCW018235 {ECO:0000313|EMBL:EEC06115.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06115.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06115.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018235-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018235-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010572756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011116807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS714433; EEC06115.1; -; Genomic_DNA.
DR RefSeq; XP_002403363.1; XM_002403319.1.
DR AlphaFoldDB; B7PHP3; -.
DR STRING; 6945.B7PHP3; -.
DR PaxDb; 6945-B7PHP3; -.
DR EnsemblMetazoa; ISCW018235-RA; ISCW018235-PA; ISCW018235.
DR KEGG; isc:IscW_ISCW018235; -.
DR VEuPathDB; VectorBase:ISCI018235; -.
DR VEuPathDB; VectorBase:ISCP_008351; -.
DR VEuPathDB; VectorBase:ISCW018235; -.
DR HOGENOM; CLU_399733_0_0_1; -.
DR InParanoid; B7PHP3; -.
DR OMA; HIPESNE; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IBA:GO_Central.
DR GO; GO:0019903; F:protein phosphatase binding; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; IBA:GO_Central.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24155:SF11; CASKIN, ISOFORM B; 1.
DR PANTHER; PTHR24155; OSTEOCLAST-STIMULATING FACTOR 1; 1.
DR Pfam; PF00536; SAM_1; 2.
DR SMART; SM00454; SAM; 2.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PHP3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 25..88
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 113..177
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 221..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..238
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..433
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 75047 MW; 2344481D6574C2E4 CRC64;
MLGLLNYVSV YVSTSLICSG LFVGRDTEVL TTWLKNLHFE EYVHLFLQAG YDMPTISRMT
PEDLTAIGIT KPAHRRKLKS EISNLNIPDG IPDYKPASRY LHSFVLSSQA VTNPLDTLLT
WLKLLRLEQY YGSLCQQGYH TVDRAADLTW EDLEDIGMQK LGHQKKMMLA IKKIRDLNSG
LRRSGNYGDI RHSSIDMGQV LSQRTTAQGL IPLGHPYHHA VPPPPPAQEA PPPHANAVPL
SRPEGDPAPQ LRTFRQQSPP RFHRAGSGES LLQGQPHFGG PLYQHQGALG ASDLYQHDFL
AMQVRSPNRG RSLESLEDGG TAYQGGHPPG QYQYQGSYQQ QQGYPQQGPS PDWYQMVSSW
RQHGYDTDSE LVRQVSHHGY DYGYEPDGTA TLHRPRGLVK PRPVAKVTAR ALLDSPDLEF
EPKEADPKLG SDWESGKRCA PAPPKRTNSI RRQQEANMAE TAFATCVQSL TSRFTMATSQ
DEPPLPPPPP AAAEEDEPPP PPLPAPPPAS SSSTLTSSSS STSSDGELSP SGTLIRRKDS
GGSSVSSESL PFANENVGTI KQRPGEAPPA PPPHGGGCVA DGAERRSSPT DGMSELAPKR
SPSGWRDVPQ DLRPVASRDK YSAPQQRPAI PPRPTDKLSG APSALGRSLP PLPPPSSSSS
GDVIDDIEHM LASLTDQLDA MLECELSNP
//
