ID B7PI59_IXOSC Unreviewed; 208 AA.
AC B7PI59;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=(S)-2-hydroxy-acid oxidase, putative {ECO:0000313|EMBL:EEC06281.1, ECO:0000313|EnsemblMetazoa:ISCW004675-PA};
DE EC=1.1.3.15 {ECO:0000313|EMBL:EEC06281.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW004675 {ECO:0000313|EMBL:EEC06281.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06281.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06281.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW004675-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW004675-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; ABJB011107969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS716965; EEC06281.1; -; Genomic_DNA.
DR RefSeq; XP_002404424.1; XM_002404380.1.
DR AlphaFoldDB; B7PI59; -.
DR STRING; 6945.B7PI59; -.
DR PaxDb; 6945-B7PI59; -.
DR EnsemblMetazoa; ISCW004675-RA; ISCW004675-PA; ISCW004675.
DR KEGG; isc:IscW_ISCW004675; -.
DR VEuPathDB; VectorBase:ISCI004675; -.
DR VEuPathDB; VectorBase:ISCW004675; -.
DR HOGENOM; CLU_1323764_0_0_1; -.
DR InParanoid; B7PI59; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003973; F:(S)-2-hydroxy-acid oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000262; FMN-dep_DH.
DR InterPro; IPR037396; FMN_HAD.
DR PANTHER; PTHR10578:SF107; FMN HYDROXY ACID DEHYDROGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10578; S -2-HYDROXY-ACID OXIDASE-RELATED; 1.
DR Pfam; PF01070; FMN_dh; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEC06281.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 1..208
FT /note="FMN hydroxy acid dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51349"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC06281.1"
FT NON_TER 208
FT /evidence="ECO:0000313|EMBL:EEC06281.1"
SQ SEQUENCE 208 AA; 23276 MW; A5166564FD78E14E CRC64;
QRLRLRPRVL KNVAQRNMEV TLLGDQRLSM PLAISPTAFQ KMAHSDGELA TARAARRAGT
LMVLSIYSTT SFEDVRQAAP EGLQWFQLYI SPDREVTKAL VIRAEKAGYK ALVVTVDLPV
PGKSSSATKS GFKPPRVPKC STIYVSIELM MSPEIARQNA LIDCRITLKR SCIIVRLLLF
KVLIQNFNKN APEGYLDLKK YVDFISAH
//
