ID B7PI86_IXOSC Unreviewed; 432 AA.
AC B7PI86;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW004235 {ECO:0000313|EMBL:EEC06308.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06308.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06308.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW004235-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW004235-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR EMBL; ABJB010021569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010166538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010177814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010546748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS717658; EEC06308.1; -; Genomic_DNA.
DR RefSeq; XP_002404665.1; XM_002404621.1.
DR AlphaFoldDB; B7PI86; -.
DR STRING; 6945.B7PI86; -.
DR PaxDb; 6945-B7PI86; -.
DR EnsemblMetazoa; ISCW004235-RA; ISCW004235-PA; ISCW004235.
DR KEGG; isc:IscW_ISCW004235; -.
DR VEuPathDB; VectorBase:ISCI004235; -.
DR VEuPathDB; VectorBase:ISCP_026038; -.
DR VEuPathDB; VectorBase:ISCW004235; -.
DR HOGENOM; CLU_005912_11_0_1; -.
DR InParanoid; B7PI86; -.
DR OMA; RHTMSEH; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF201; SODIUM_HYDROGEN EXCHANGER 8; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 30..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..357
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT NON_TER 432
FT /evidence="ECO:0000313|EMBL:EEC06308.1"
SQ SEQUENCE 432 AA; 48300 MW; F4326EC093D7D8CF CRC64;
MFFLVLLPPI IYESGYNLHK GNFFQNIGSI LIFSIVGTTI SALVIGGGVY LLGLADVAYR
LDFAESFAFG SLISAVDPVA TLAIFHALDI DPILNMLVFG ESILNDAVSI VLATTILESG
SPEMASLTTG QLVFHGVQRF FLVFFASAGI GVAFALAAAL ISLHLGFDVH LLKYVDLRKN
PSLEFGMMLV FVYAPYGLAE GIHLSGIMAI LFNGVVMSHY THFNLSSVTQ ITMQQTLRTL
SLIAETSVFA YLGLAIFSYR LIIKPSLIIW SIVLCLLGRA ANIYPLSFLL NYFREHKITK
KMMFIMWYSG LRGAIAYALA MHLDFDDEKR HVVVTTTLII VLFTILVIGG STMPLMKFLK
ADKQTTRRKR RRTRKVTLSK TKEMGQTIDA EHLSELTEEE YEVNFMKSNI KGFILLDIKY
LIPFFTRRFT QK
//
