ID B7PIC9_IXOSC Unreviewed; 1153 AA.
AC B7PIC9;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Proto-oncogene receptor tyrosine protein kinase ret, putative {ECO:0000313|EMBL:EEC06351.1, ECO:0000313|EnsemblMetazoa:ISCW003506-PA};
DE EC=2.7.10.1 {ECO:0000313|EMBL:EEC06351.1};
GN ORFNames=IscW_ISCW003506 {ECO:0000313|EMBL:EEC06351.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06351.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06351.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW003506-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW003506-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR EMBL; ABJB010071694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010276834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010387936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010429947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010450687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010498151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010849151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010917952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS718147; EEC06351.1; -; Genomic_DNA.
DR RefSeq; XP_002404815.1; XM_002404771.1.
DR AlphaFoldDB; B7PIC9; -.
DR STRING; 6945.B7PIC9; -.
DR PaxDb; 6945-B7PIC9; -.
DR EnsemblMetazoa; ISCW003506-RA; ISCW003506-PA; ISCW003506.
DR KEGG; isc:IscW_ISCW003506; -.
DR VEuPathDB; VectorBase:ISCI003506; -.
DR VEuPathDB; VectorBase:ISCP_018730; -.
DR VEuPathDB; VectorBase:ISCW003506; -.
DR HOGENOM; CLU_276255_0_0_1; -.
DR InParanoid; B7PIC9; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF485; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:EEC06351.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000313|EMBL:EEC06351.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:EEC06351.1}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1153
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010826169"
FT DOMAIN 766..1034
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 629..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1094
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 800
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1153 AA; 126163 MW; 9562271CFFFB864F CRC64;
MGAVASLRST DILAALWVST QAVVDVGASK NRGPTEMLMK LLLVDERWST IMLVRGTQLL
RPSRTRRAVR GTRRGDPAHI VSERCIRSRR HVAPLYENLA DIGRALVTLY EHEAPAGRPP
PVLVEWPQRV PSVRTVDVLS DQPAGLPFFE AHAAVVFLGP PQVHGDPKGH TPELPVLSYA
LDTSGTSDAQ SEGIFTIDCR SGQLSLTRPF PVSRGNKQQN PPTWNLVLEA RVQWDCRNCS
SKFPVRVRQI RSSSRSTLCE NSRRVCFPPG LRNPEYAYSE GVSSGTVVDV LRPQAMAVLC
PTLKPRYTLI QERSSPLSVD SASGLLSLSK GLHWNDPPVL ARVRCFTGEG PAAETDVSVF
VWDLDDHPPR LPAKASLECR ITLDKLEAHT KLDCPLSILD GDSLDANKFR VRLDGDDLEL
FKAKTPLDEY FLGERKETFV NVALYPRKSG LSFPGQEYTF KVIVEDVDLV RADLNNKVIF
TVIIANSSVQ RVPLQLQEIY NISMSRSAAA LARMLFLWKN VQLSKSQCLS SCGPGAPDGR
CRWREGPEGR YLSSGYSTCT GDRATCPDGT CDELETLRPE LCPQDCTQHV VGEALLRQPG
RGIKAAQGIC SCASADSCTC TKLVSRPESR DSVVGGHEEP KNPGTLHSAG PDTAEAAEAS
SSAVSSPSCG VVCLASLCLC GLALFGATLA GLLFARRRRA AAKHKYLGSR ASLSVPSDYV
DGRRHPQHPQ QESADAGTQA SAPLVSASPL AKLVVDSQWE FPRENLFLEQ SLGEGEFGKV
VRARARDIAG VRGYSTVAVK MLKGNSTPAE EQDLLSEFCM LKEVNHPNVI RLLGGCTSKG
GPLYVIVEYA ELGSLLSVLR RSRQLAADRA TVVCNPTYMS QGASTAEGAS DEGASDGAGL
LSHGDLLCYA WQIAKGMAYL ADVKMVHRDL AARNILLAAG NVIKISDFGL SRDVYEGDTW
SFGVVLWEIV TLGATPYPGV GPEYLFQLLK SGYRMHRPEG CSPHIYRMMQ CCWQSRPQER
PSFKELTQKL ESILQDSASY LDLNVAQQRS YYNLNLPTGS LKQLLDSDDD VNTPESEYGR
IEFKSQRSLD RRDSSPGENT APPVHPKRAS SHESRTHSHR KDDLPRPKAA PQDSGVKSRS
QKRGCFISSF VQR
//
