ID B7PJR7_IXOSC Unreviewed; 442 AA.
AC B7PJR7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Glutamate-gated metabotropic ion channel receptor, putative {ECO:0000313|EMBL:EEC06839.1, ECO:0000313|EnsemblMetazoa:ISCW004657-PA};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW004657 {ECO:0000313|EMBL:EEC06839.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06839.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06839.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW004657-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW004657-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; ABJB010256864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010735525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010853182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011010859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS727862; EEC06839.1; -; Genomic_DNA.
DR RefSeq; XP_002408425.1; XM_002408381.1.
DR AlphaFoldDB; B7PJR7; -.
DR STRING; 6945.B7PJR7; -.
DR PaxDb; 6945-B7PJR7; -.
DR EnsemblMetazoa; ISCW004657-RA; ISCW004657-PA; ISCW004657.
DR KEGG; isc:IscW_ISCW004657; -.
DR VEuPathDB; VectorBase:ISCI004657; -.
DR VEuPathDB; VectorBase:ISCP_026881; -.
DR VEuPathDB; VectorBase:ISCW004657; -.
DR HOGENOM; CLU_005389_2_1_1; -.
DR InParanoid; B7PJR7; -.
DR OMA; FWKEADK; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd06362; PBP1_mGluR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF176; MANGETOUT, ISOFORM G; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|EMBL:EEC06839.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..442
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010959771"
FT DOMAIN 62..442
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC06839.1"
FT NON_TER 442
FT /evidence="ECO:0000313|EMBL:EEC06839.1"
SQ SEQUENCE 442 AA; 49514 MW; 8FAB1801C94B1104 CRC64;
LAAALALLVW RLPGPARALP GKWPIQRMTN FSGDILLGAL FPVHERNATY ECGRIQDEGV
QQLEALLYTL QKINNDSALL PGVTLGVLAL DSCDSTAYAL EQSLDFVKGF IARSSMGFSC
ADGSSPAYRS GAFDRVVGVI GGQSSAVSIQ LANLLRLFRV PQVSYQSTSP TLSNKDKFGY
FFRTVPSDVN QAHAILELLR AFRWTYVSVV YSDTDYGNKG YDKLQELAAR YRICLSNPQS
IPGDHFAEAD YDAVLRSLTH KSNARVVVVF TDKRTARSLM RAAWRRRDRF VWIGSDAWSG
LESVAQGHEE IVEGAITVSP MVQSLQGFDQ YFNQLTPDNN VLDPWFPEYW EEKFQCRLPE
FQVISARQAY RGLKSTKVDF RFYAGYRGLQ FVRDAAYAFA HALHDLQRDR CGAQHQGLCP
AMDKGIQGHT LKRYLEKVAF KG
//
