ID B7PLX7_IXOSC Unreviewed; 836 AA.
AC B7PLX7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Calmodulin-binding transcription activator, putative {ECO:0000313|EMBL:EEC07599.1, ECO:0000313|EnsemblMetazoa:ISCW018640-PA};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW018640 {ECO:0000313|EMBL:EEC07599.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC07599.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC07599.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018640-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018640-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: May interact with calmodulin. {ECO:0000256|ARBA:ARBA00029480}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Target cell membrane {ECO:0000256|ARBA:ARBA00004175}.
CC -!- SIMILARITY: Belongs to the CAMTA family.
CC {ECO:0000256|ARBA:ARBA00008267}.
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DR EMBL; ABJB010157498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010419720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010536001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010709504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010932324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010942864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS744030; EEC07599.1; -; Genomic_DNA.
DR RefSeq; XP_002434775.1; XM_002434730.1.
DR AlphaFoldDB; B7PLX7; -.
DR PaxDb; 6945-B7PLX7; -.
DR EnsemblMetazoa; ISCW018640-RA; ISCW018640-PA; ISCW018640.
DR KEGG; isc:IscW_ISCW018640; -.
DR VEuPathDB; VectorBase:ISCI018640; -.
DR VEuPathDB; VectorBase:ISCP_034728; -.
DR VEuPathDB; VectorBase:ISCW018640; -.
DR HOGENOM; CLU_001807_0_0_1; -.
DR InParanoid; B7PLX7; -.
DR OMA; PEHIKNE; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0044231; C:host cell presynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00102; IPT; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005559; CG-1_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23335; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA; 1.
DR PANTHER; PTHR23335:SF0; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF03859; CG-1; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00015; IQ; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51437; CG_1; 1.
DR PROSITE; PS50096; IQ; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Membrane {ECO:0000256|ARBA:ARBA00023298};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699};
KW Presynaptic neurotoxin {ECO:0000256|ARBA:ARBA00023028};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Target cell membrane {ECO:0000256|ARBA:ARBA00022537};
KW Target membrane {ECO:0000256|ARBA:ARBA00023298};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 1..42
FT /note="CG-1"
FT /evidence="ECO:0000259|PROSITE:PS51437"
FT REGION 94..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC07599.1"
FT NON_TER 836
FT /evidence="ECO:0000313|EMBL:EEC07599.1"
SQ SEQUENCE 836 AA; 92092 MW; A607FAD26D554AFD CRC64;
CIYGCYVHSA ILPTFHRRCY WLLQNPDIVL VHYLNVPYSD DNKMVIAPTL SYCADKKEWT
KEELGPRERG SRGGALFDDS LDLSHDGIQK TLTANLVSSR RRPSSDSSSG GVLVKTENVG
GHADADPVDL NPMDFIDNDI STPDEEVFNL DTFDMLTDLP NWDDFNSDLA VTTTGTGAVL
SSSSNMSGNS LPLVHSSSGS SNKSAGTQSS SHSGMTYREG TANITDYSPD WSYTEGGVKV
LITGPWYSSS SPYTILFDGV SVPTTLVQSG VLRCFCPAHE AGLVTLQVAC EGFVISNSVI
FEYREQPLVS AQKAKDWFGV DGEWHGTLKF SLLERLEMVE ARLSFGNKGA IFPGVLAQVS
GFADKQRPFE ERLVSLCGEL RWGSWVHRGD CSPIKALSRP DLSLLHLAAA LGFSRLARTL
LLWRQENPSL TLDAEVDPLG RDARECTPLH WACARGQREV ALLLLQWDAS ALRVTSADGQ
TPAGLARQST HPSLDEELEQ GARKQQHAVQ DTSSVARYAL QVYRASADGG SSMGSSFSTE
AESSKRSSVD SGMCEGLASL PASSLLSSRL FNLKSISLFK SLNVFLTGTS KDFGNSYDTL
FVIPILPQNI SILIFQKAYC KHILLRSSPL GRRRESHGGV CDLAGPSCIV DSGVAAVPPD
SRVLTLAEQI IAALPERIKA SREVEEEDEE DAMEAEGLFL LLSPDPHSPG LSAMCSMDDP
PPPLLSDEFS FEFSDHNYRL FMRDFSNLTL SDKEQRELYE AAKIIQKAYR SYKGRKRQEE
QEKERAAAVL IQSYYRRYKQ YMYYKQMTKA AAESFPGWCE QHKRFKKSPE GESSGA
//
