ID B7PLZ8_IXOSC Unreviewed; 253 AA.
AC B7PLZ8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Cytochrome B561, putative {ECO:0000313|EMBL:EEC07620.1, ECO:0000313|EnsemblMetazoa:ISCW005388-PA};
GN ORFNames=IscW_ISCW005388 {ECO:0000313|EMBL:EEC07620.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC07620.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC07620.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW005388-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW005388-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ABJB010044518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010060074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010088308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010330593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010428060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010638719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010640996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010858326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS744632; EEC07620.1; -; Genomic_DNA.
DR RefSeq; XP_002434796.1; XM_002434751.1.
DR AlphaFoldDB; B7PLZ8; -.
DR STRING; 6945.B7PLZ8; -.
DR PaxDb; 6945-B7PLZ8; -.
DR EnsemblMetazoa; ISCW005388-RA; ISCW005388-PA; ISCW005388.
DR KEGG; isc:IscW_ISCW005388; -.
DR VEuPathDB; VectorBase:ISCI005388; -.
DR VEuPathDB; VectorBase:ISCP_002212; -.
DR VEuPathDB; VectorBase:ISCW005388; -.
DR HOGENOM; CLU_069712_1_1_1; -.
DR InParanoid; B7PLZ8; -.
DR OMA; EFHYHPT; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR CDD; cd08764; Cyt_b561_CG1275_like; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR InterPro; IPR043205; CYB561/CYBRD1-like.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR PANTHER; PTHR10106; CYTOCHROME B561-RELATED; 1.
DR PANTHER; PTHR10106:SF0; LYSOSOMAL MEMBRANE ASCORBATE-DEPENDENT FERRIREDUCTASE CYB561A3; 1.
DR Pfam; PF03188; Cytochrom_B561; 1.
DR SMART; SM00665; B561; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
PE 1: Evidence at protein level;
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022617};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PLZ8};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..229
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
SQ SEQUENCE 253 AA; 27873 MW; B36821F84C076401 CRC64;
MDPYDRELGT VQDLRGFTLG YSLVQVLGLS AVLLVTIWAS NFMGGFSGPS NPKLEFNYHP
VFMVLGMVFL YGNGILVYRA LRTERKSRLK LVHGALMALA FLCAVAALKT VFDSHNLNQP
AAIPNLYSLH SWLGLTAVLL FCMQLLTGFV SFLFPGVRQW LRAQYLPLHV FFGLAIFGLA
VATALLGISE KLFFRLASNY SNLPGEAALG NLLGLCLLSF AVLVVFLATR TSYRRTPLPE
EASLPLQPHS PME
//
