ID B7PNV7_IXOSC Unreviewed; 438 AA.
AC B7PNV7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Protein kinase C and casein kinase substrate in neurons protein, putative {ECO:0000313|EMBL:EEC08279.1, ECO:0000313|EnsemblMetazoa:ISCW018948-PA};
GN ORFNames=IscW_ISCW018948 {ECO:0000313|EMBL:EEC08279.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC08279.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC08279.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018948-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018948-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010018956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010199349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010337503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010374336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010418809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010592310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010612057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010936484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS754808; EEC08279.1; -; Genomic_DNA.
DR RefSeq; XP_002435449.1; XM_002435404.1.
DR AlphaFoldDB; B7PNV7; -.
DR STRING; 6945.B7PNV7; -.
DR PaxDb; 6945-B7PNV7; -.
DR EnsemblMetazoa; ISCW018948-RA; ISCW018948-PA; ISCW018948.
DR KEGG; isc:IscW_ISCW018948; -.
DR VEuPathDB; VectorBase:ISCI018948; -.
DR VEuPathDB; VectorBase:ISCP_037503; -.
DR VEuPathDB; VectorBase:ISCW018948; -.
DR HOGENOM; CLU_030752_0_0_1; -.
DR InParanoid; B7PNV7; -.
DR OMA; DRVEKCS; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0097320; P:plasma membrane tubulation; IBA:GO_Central.
DR GO; GO:0030100; P:regulation of endocytosis; IBA:GO_Central.
DR CDD; cd07655; F-BAR_PACSIN; 1.
DR CDD; cd11843; SH3_PACSIN; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF11; SYNDAPIN, ISOFORM C; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Kinase {ECO:0000313|EMBL:EEC08279.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PNV7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:EEC08279.1}.
FT DOMAIN 11..281
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 379..438
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 161..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 49661 MW; 1129E72C70AAA07F CRC64;
MSHHSDEALL VAGSESFWEP GNYKRTSKRT EDGHRLCSDL VQLVQERSEV EKAYAKGLRA
WARKWADLID KGPEYGTTEA AWKGALLEAE RTCEMHLRVR DRLLNDVVPQ VKGWQKENFH
RSMMQLRERR ELDEAFKKAQ KPWAKLLAKV DRSRTDYHAA CKGERSATNQ ERNAGADTSL
SPDQVSVSLS LRFGGAAGEL QRTRERYEAS LQEINEYNAK YMEDMTVVFD KCQEFEQRRL
HFFKEMLFGI HACLNISTDP ELPQIYEEYR HTIQNADASK DLKWWSNNHG VGMAMNWPQF
EEYTPEVQQI HRKEKKALDA GGITLTSVST RADGAPVATA PKAGSGPKRD KDVKDGGTAS
NHAALNARNN PSANNNNTCP GVPVRALYDY EGAEADELSF KQGDQFEKLE DEDEQGWCKG
RKDGRVGLYP ANYVEVVP
//
