ID B7PP47_IXOSC Unreviewed; 202 AA.
AC B7PP47;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 11-DEC-2019, entry version 62.
DE SubName: Full=CDK2- associated dual specificity phosphatase, putative {ECO:0000313|VectorBase:ISCW006791-PA};
DE SubName: Full=CDK2-associated dual specificity phosphatase, putative {ECO:0000313|EMBL:EEC08369.1};
DE EC=3.1.3.16 {ECO:0000313|EMBL:EEC08369.1};
GN Name=8051878 {ECO:0000313|VectorBase:ISCW006791-PA};
GN ORFNames=IscW_ISCW006791 {ECO:0000313|EMBL:EEC08369.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945 {ECO:0000313|Proteomes:UP000001555};
RN [1] {ECO:0000313|EMBL:EEC08369.1, ECO:0000313|Proteomes:UP000001555, ECO:0000313|VectorBase:ISCW006791-PA}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555,
RC ECO:0000313|VectorBase:ISCW006791-PA}, and Wikel colony
RC {ECO:0000313|EMBL:EEC08369.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|VectorBase:ISCW006791-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|VectorBase:ISCW006791-PA};
RG VectorBase;
RL Submitted (FEB-2017) to UniProtKB.
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DR EMBL; ABJB010807823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS755904; EEC08369.1; -; Genomic_DNA.
DR RefSeq; XP_002435539.1; XM_002435494.1.
DR EnsemblMetazoa; ISCW006791-RA; ISCW006791-PA; ISCW006791.
DR GeneID; 8051878; -.
DR KEGG; isc:IscW_ISCW006791; -.
DR VectorBase; ISCW006791-RA; ISCW006791-PA; ISCW006791.
DR eggNOG; KOG1720; Eukaryota.
DR eggNOG; COG2453; LUCA.
DR InParanoid; B7PP47; -.
DR KO; K14167; -.
DR OMA; ALPGCKY; -.
DR OrthoDB; 1539111at2759; -.
DR PhylomeDB; B7PP47; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0007050; P:cell cycle arrest; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR008425; CDK_inhib_3.
DR InterPro; IPR022778; CDKN3.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR Pfam; PF05706; CDKN3; 1.
DR PIRSF; PIRSF037322; CDKN3; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EEC08369.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 109..167
FT /note="TYR_PHOSPHATASE_2"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT ACT_SITE 132
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR037322-1"
SQ SEQUENCE 202 AA; 22576 MW; 4F59F8EAF398BA49 CRC64;
MDSSDEEVSG DYLKPATPLK IDWLDLSMFG YPDSVGLSGL PGCKFKDSWR DTAHDLEYLK
LEDVSDVFVL CTRGELTLYR VPSLLTEYES HGITVHHHPF QDGTAPGIEQ VLNILKEIGK
VIEQGKRALV HCFGGLGRTG VVAACLLLNL DDGVTPEYVV RKVQELRGTR AIQTVKQYNF
IHDFRSLRDM YLGDSDSKLA TE
//
