ID B7PQS2_IXOSC Unreviewed; 231 AA.
AC B7PQS2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Urease accessory protein ureG, putative {ECO:0000313|EMBL:EEC08944.1, ECO:0000313|EnsemblMetazoa:ISCW018576-PA};
GN Name=8052301 {ECO:0000313|EnsemblMetazoa:ISCW018576-PA};
GN ORFNames=IscW_ISCW018576 {ECO:0000313|EMBL:EEC08944.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC08944.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC08944.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018576-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018576-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. UreG
CC subfamily. {ECO:0000256|ARBA:ARBA00005732}.
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DR EMBL; ABJB010940623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS766923; EEC08944.1; -; Genomic_DNA.
DR RefSeq; XP_002436114.1; XM_002436069.1.
DR AlphaFoldDB; B7PQS2; -.
DR STRING; 6945.B7PQS2; -.
DR PaxDb; 6945-B7PQS2; -.
DR EnsemblMetazoa; ISCW018576-RA; ISCW018576-PA; ISCW018576.
DR GeneID; 8052301; -.
DR KEGG; isc:IscW_ISCW018576; -.
DR VEuPathDB; VectorBase:ISCI018576; -.
DR VEuPathDB; VectorBase:ISCP_023729; -.
DR VEuPathDB; VectorBase:ISCW018576; -.
DR HOGENOM; CLU_072144_0_0_1; -.
DR InParanoid; B7PQS2; -.
DR OMA; KMRGDKP; -.
DR OrthoDB; 5484572at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR CDD; cd05540; UreG; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_01389; UreG; 1.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004400; UreG.
DR NCBIfam; TIGR00101; ureG; 1.
DR PANTHER; PTHR31715; UREASE ACCESSORY PROTEIN G; 1.
DR PANTHER; PTHR31715:SF0; UREASE ACCESSORY PROTEIN G; 1.
DR Pfam; PF02492; cobW; 1.
DR PIRSF; PIRSF005624; Ni-bind_GTPase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nickel insertion {ECO:0000256|ARBA:ARBA00022988};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PQS2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 25..192
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
SQ SEQUENCE 231 AA; 24935 MW; 14A113574AA4858B CRC64;
MDGPGSFRQR EAFRTRDDFG KRAFTVGVGG PVGSGKTALV LALCQKLRDT HNLCVVTNDI
FTREDWEFLC RNKALPEERM RAIETGGCPH AAIREDYSAN MEAVRELTKK FSPEILLLES
GGDNLAANFS RELSDFIIYV IDVAGGDKIP RKGGPGITQS DLLVINKTDL AGAVGADMDV
MVRDAAKMRQ GGPTLLVQAT HDVGVDQVAR LVLQAAKDAG VPLKCRAAES C
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