ID B7PT76_IXOSC Unreviewed; 1917 AA.
AC B7PT76;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Midasin, putative {ECO:0000313|EMBL:EEC09798.1, ECO:0000313|EnsemblMetazoa:ISCW019504-PA};
DE EC=3.4.21.53 {ECO:0000313|EMBL:EEC09798.1};
DE EC=6.6.1.2 {ECO:0000313|EMBL:EEC09798.1};
GN ORFNames=IscW_ISCW019504 {ECO:0000313|EMBL:EEC09798.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC09798.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC09798.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW019504-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW019504-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010174647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010225774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010329623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010392060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010634991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010635310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010960432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011097603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS784171; EEC09798.1; -; Genomic_DNA.
DR RefSeq; XP_002403983.1; XM_002403939.1.
DR STRING; 6945.B7PT76; -.
DR PaxDb; 6945-B7PT76; -.
DR EnsemblMetazoa; ISCW019504-RA; ISCW019504-PA; ISCW019504.
DR KEGG; isc:IscW_ISCW019504; -.
DR VEuPathDB; VectorBase:ISCI019504; -.
DR VEuPathDB; VectorBase:ISCP_027108; -.
DR VEuPathDB; VectorBase:ISCW019504; -.
DR HOGENOM; CLU_000050_1_0_1; -.
DR InParanoid; B7PT76; -.
DR OMA; NRFIQVY; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051116; F:cobaltochelatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 5.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Hydrolase {ECO:0000313|EMBL:EEC09798.1};
KW Ligase {ECO:0000313|EMBL:EEC09798.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PT76};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 486..727
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 882..1033
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1179..1331
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1517..1661
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 1917 AA; 210473 MW; FB0C25BE8E92A70B CRC64;
MIACPGETDV WSLSNYDLYN AVALLCEQSR KPPQELRQWL SQKNWSPSTR GSLLDQLSQL
LLRGDSTADL VAQLCCPLLP ELLDRCARHP RHRKRLCLVL GRLAARFPAA AHFAEAYLKD
QGCLPALLEG MLGEGHCEAP AAKRPRVETP LDVVGCCLQL LSAWPQQLRS RWDWSPLLPL
LQHSSAPVRW LATEVALASL RPPTWPPCSE SPGLLWTHSD LSAGVACISG LLLPRSLTAG
NKPLDKALHQ GCWLLLEDLE RASPDVSSLL LPVLQHGALP GLPSNPGFQL LATHREGGHR
GGGALLPTEA LWASVTLDHP SREEMEQMII HEWPQLEPLA GRLLDMLCQL RERGSPVRRA
VSQRDLVKLC RRLTGREFTL EGVRVAEEAF QDAMDCLCQS VREPEQRLAL AQAVGAKLGL
PKAQVGAYFT ANHKPTILEN STAVTVGRVT LPRRGRGRNR ESNSGVFAGT RPALALLEQL
AAAVANREPV LLVGETGVGK TAAVQHLARL TGNSLTVLNM SQQSDSTDLL GGFKPVDVKI
LMMPLRDEFE QLFAASFCLA PNAKFLSHVT TCFSGRHWQA LFRLMRHSQQ CAITGVPAGS
ASDVDQLESW RQFGQRLEQV QLQVQQAERG LAFAFVEGAL VRALETGAWV LLDEINLAEG
EALESLAPVL DGSSPVLFER GDQEPVPRHP NFRLFACMNP ATDVGKKDLP AGIRSRFTEV
YLEEPLDACD LELVADAYLG GGPTRPTVEL YLDLRRAAQE SLADGTGRRP HYSLRTLCRA
LRYAAGDPCG SWAHSLYQGF CLSFLTALDR GSHPAVESLI RKRLIGQKVP RSPAAPLDRP
SVQLEGYWVA LGPLDSVSPE GYVLTTTVRR NLRDLARAAA CGRHPVLLQG ETSAGKTSLV
RWLAARTGHV CMRLNNHEHT DLEEYLGSYG AEPGTGRLVF REGVLVEAMR QGHWIVLDEL
NLACSEILEA LNRVLDDNRE LFVPETQETI RAHPHFMLFA TQNPPGRYGG RKVLSRAFRN
RFLELHFEEL PPEELAGILK ERCKLPPSYG ARMVAVMCEL QLRRRETGVF AGRHGYMTLR
DLFRWAERYR RTESPAGGFF NWNQYLAEEG YALLAGRVRR PQEEQLVSEV LAKHFKCKVD
PERLFSRVPC EVPPPGFSHL VWTADARRLA ALLERAWRFE EPVLLVGDTG CGKTTLCELW
AALQGQRLRS VSCHLHSEAG DLLGGLRPGR QAGGPLFEWA DGPLVEAMAR GDAFLVDEIN
LAEDAVLERL NSLLEPERTL LLPEEGGRQL VAHPQFRLLA TMNPGGDFGK RELSPALRNR
FTEIWCPSTV SSADLAAIAD HNLGADVRLG SLTLGAAMAD FLDWIRSDEL GHRCVATARD
VLAWADLVKR CTSSGAMSLA ASYVHGARLA FLDGLGTGTT GSEGPSAVTA LRVRALAVLQ
RQLVAQLTSS GVPEDAWQAL RDCADMDVVQ DSRGLHLGPF LLPTGPLGAV SLEEAHYSLR
AGTPRANALR LVRALQLDKP VLLEGPPGVG KTSLVTALAR ASGHPITRIN LSEQTDISDL
FGADLPVEGG GAGQFAWRDG PLLRALREGH WVLLDELNLA SQSVLEGLNA CLDHRGAVFV
PELNRSFQVA RGRTRLFGCQ NPYRQGGARR GLPRSFLNRF TQLALEPLGQ RDLEVLARCL
HPGLPESTLR SMVLFNQELA NQVQDQCLWG TLGSPWEFNL RDVSRWACMM EVGPPNAGDH
VAIAYASRMR SPQDREKVLR LYEKVFGEAA PRRESEVRLA NGWLRVGHAL LARGYMGNDP
PSRDWRSLRL LHVQATTLEA LAKCVECGFA ALLVGPSGAG KSALVHTLAG LAGHPLAVFP
VGAATDALEL LGNFEQVRLC QQYRGDEGLS WLGLARCPGH HSVVSLQRIE FCFRASL
//
