ID B7PTG6_IXOSC Unreviewed; 481 AA.
AC B7PTG6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Vacuole membrane protein, putative {ECO:0000313|EMBL:EEC09888.1, ECO:0000313|EnsemblMetazoa:ISCW007971-PA};
GN Name=8031108 {ECO:0000313|EnsemblMetazoa:ISCW007971-PA};
GN ORFNames=IscW_ISCW007971 {ECO:0000313|EMBL:EEC09888.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC09888.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC09888.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW007971-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW007971-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the VMP1 family.
CC {ECO:0000256|ARBA:ARBA00038098}.
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DR EMBL; ABJB010145156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010187107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010333299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010368120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010697092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS785766; EEC09888.1; -; Genomic_DNA.
DR RefSeq; XP_002404400.1; XM_002404356.1.
DR AlphaFoldDB; B7PTG6; -.
DR STRING; 6945.B7PTG6; -.
DR PaxDb; 6945-B7PTG6; -.
DR EnsemblMetazoa; ISCW007971-RA; ISCW007971-PA; ISCW007971.
DR GeneID; 8031108; -.
DR KEGG; isc:IscW_ISCW007971; -.
DR VEuPathDB; VectorBase:ISCI007971; -.
DR VEuPathDB; VectorBase:ISCP_018961; -.
DR VEuPathDB; VectorBase:ISCW007971; -.
DR HOGENOM; CLU_033298_0_1_1; -.
DR InParanoid; B7PTG6; -.
DR OMA; EEPYDKR; -.
DR OrthoDB; 996161at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0006914; P:autophagy; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR10281; MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED; 1.
DR PANTHER; PTHR10281:SF1; VACUOLE MEMBRANE PROTEIN 1; 1.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50800; SAP; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PTG6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 143..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..48
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 53719 MW; 7C9C5E079D846BEE CRC64;
MGPKNRRPPS RREYKSLSKD ALRQELRSRG IKSTGKKSDM VKRLEKWDHE RMADTSDAGL
TMRQRKTSES EGPASNGGLS AFGSAGEGGA FAGFTKMEML NDCVDRKSLV LWRRPAMTVR
YFVSELLVLT WEMGFRLWRN RRHVMAALLV LLLCMLAYCF EGSHQRYITF IEKKVLWCAY
WVGLGVLSSV GLGTGLHTFL LYLGPHIAAV TLAAHECGSV DFPEPPYPDE IICPEDSGPG
SGGTIGILKV MSKVRLEAFM WGAGTALGEL PPYFMAKAAR LSGNEDLEDL EELEELMEKE
KSKDLSFLDK AKLAVEKLVE RVGFLGILAC ASIPNPLFDL AGITCGHFLV PFWTFFGATL
IGKAIIKMHI QKLFVIIAFN EHHVELLLKT LRYIPYVGKF LQAPFKEFLA KQKAKLHRKV
GAEVPQEGSL LSWLFEKLVM AMVAYFVLSI INSMAQNYHR RLSKGQKGPQ GPAILHKVAT
S
//
