ID B7PTU4_IXOSC Unreviewed; 643 AA.
AC B7PTU4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=PHD-type domain-containing protein {ECO:0000259|PROSITE:PS51533};
GN ORFNames=IscW_ISCW007361 {ECO:0000313|EMBL:EEC10016.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC10016.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC10016.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW007361-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW007361-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR EMBL; ABJB010337750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010533757; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010838031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011112755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS788271; EEC10016.1; -; Genomic_DNA.
DR RefSeq; XP_002404911.1; XM_002404867.1.
DR AlphaFoldDB; B7PTU4; -.
DR STRING; 6945.B7PTU4; -.
DR PaxDb; 6945-B7PTU4; -.
DR EnsemblMetazoa; ISCW007361-RA; ISCW007361-PA; ISCW007361.
DR KEGG; isc:IscW_ISCW007361; -.
DR VEuPathDB; VectorBase:ISCI007361; -.
DR VEuPathDB; VectorBase:ISCP_010859; -.
DR VEuPathDB; VectorBase:ISCW007361; -.
DR HOGENOM; CLU_425970_0_0_1; -.
DR InParanoid; B7PTU4; -.
DR OMA; WEENEPF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005721; C:pericentric heterochromatin; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0031297; P:replication fork processing; IBA:GO_Central.
DR CDD; cd11726; ADDz_ATRX; 1.
DR InterPro; IPR025766; ADD.
DR InterPro; IPR041430; ADD_ATRX.
DR PANTHER; PTHR46357; TRANSCRIPTIONAL REGULATOR ATRX; 1.
DR PANTHER; PTHR46357:SF1; TRANSCRIPTIONAL REGULATOR ATRX; 1.
DR Pfam; PF17981; ADD_ATRX; 1.
DR PROSITE; PS51533; ADD; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..126
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51533"
FT REGION 118..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 70923 MW; BD82ABAF2EA7AF94 CRC64;
MCITCEEQIN YFDFKKVLIH KHLKIIFCRN CYERYGDGNF QKDSSGADED CRGCAEGGSL
VVSDSCSRGF CKSCIRRNLF RKQLSCTTSL DVWNGYVSDA SPNENLVNSA DITREFSKDH
HHLQQQRPSN QLASAADSPG DTVSEDVQLR MIAETMSQIQ RALDEFSKAK EGKGADSEVL
VKTAELMHAN ALTLARITED LDRLQRRQKQ LQRMNRTRTA DKKRTLKKKT EGKGKGKTEE
DGQGGEDASD PVGDASTSEI ADESLGVAVE ARQEEVKEDE QAGKDKTKKN VAKKEDGDGK
DIACREPSAA GETPTIVLDL PEAPSLGDEF PPVAGADGED FVVKWQLPLD ELIRQFIPDE
SGPRTTRVEV ELSPSHDEAS ASRNTAAADE STAEVGGAKT RNFCDPDTDS IASSTKGDSL
CDLPIDSNKS SWEENEPFTA QTNDEQRKKR SPLSKNQKAR QALMRSLRYS GDGPSDEDSE
DDLPLRSGRI QKTTPTRRRK KWSPKKKAQE AGSDPPTPAL SGSSTPAPVG VDPPGPDDPK
LRLVPVVVLR KLPIFWDTWA EQKKRKSEND ISRLLRFPQP ARKRDRTPRK PEEAKAVVAK
SKNADTQGIQ ASVRDKSVMI KFIVVDARAA PILGGNAVKR STW
//
