ID B7PVG9_IXOSC Unreviewed; 269 AA.
AC B7PVG9;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Docking protein, putative {ECO:0000313|EMBL:EEC10591.1, ECO:0000313|EnsemblMetazoa:ISCW007256-PA};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW007256 {ECO:0000313|EMBL:EEC10591.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC10591.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC10591.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW007256-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW007256-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010582670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS799611; EEC10591.1; -; Genomic_DNA.
DR RefSeq; XP_002407926.1; XM_002407882.1.
DR AlphaFoldDB; B7PVG9; -.
DR STRING; 6945.B7PVG9; -.
DR PaxDb; 6945-B7PVG9; -.
DR EnsemblMetazoa; ISCW007256-RA; ISCW007256-PA; ISCW007256.
DR KEGG; isc:IscW_ISCW007256; -.
DR VEuPathDB; VectorBase:ISCI007256; -.
DR VEuPathDB; VectorBase:ISCP_027096; -.
DR VEuPathDB; VectorBase:ISCW007256; -.
DR HOGENOM; CLU_057256_2_0_1; -.
DR InParanoid; B7PVG9; -.
DR OMA; KMLSIEC; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd13164; PTB_DOK4_DOK5_DOK6; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21258; DOCKING PROTEIN RELATED; 1.
DR PANTHER; PTHR21258:SF56; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 157..262
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT NON_TER 269
FT /evidence="ECO:0000313|EMBL:EEC10591.1"
SQ SEQUENCE 269 AA; 29837 MW; 7AB5D609C7D0C686 CRC64;
MATDTSDIAK QGYVRVRSRN IGCARCIASG VFSIPCQGPL SLSGGTSQVW QRRWLVLRRA
AGRTPCRLEK YLEERHARLH AGQKVVLLGP AASVCRLPAS VKRHAFALAF QDGSVKAIAC
DSDLEADTWV KLMVQECLEP QSGLCAGEPD ILSPGIQKEL QEQFHVHLVP SPKLEVFGEC
LLQVTHEHVY LWDLLNPRTK LAAWPLTALR RYGSDPAKFT FEAGRHCATG EGMFVFHTLE
GEKIYSKVHQ ATLAIAEAHH RSKRLQPLP
//
