ID B7PVN6_IXOSC Unreviewed; 495 AA.
AC B7PVN6;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Neurotransmitter gated ion channel, putative {ECO:0000313|EMBL:EEC10658.1, ECO:0000313|EnsemblMetazoa:ISCW019702-PA};
GN ORFNames=IscW_ISCW019702 {ECO:0000313|EMBL:EEC10658.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC10658.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC10658.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW019702-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW019702-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010167135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010481610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010498659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010922514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010964765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS800768; EEC10658.1; -; Genomic_DNA.
DR RefSeq; XP_002408267.1; XM_002408223.1.
DR AlphaFoldDB; B7PVN6; -.
DR STRING; 6945.B7PVN6; -.
DR PaxDb; 6945-B7PVN6; -.
DR EnsemblMetazoa; ISCW019702-RA; ISCW019702-PA; ISCW019702.
DR KEGG; isc:IscW_ISCW019702; -.
DR VEuPathDB; VectorBase:ISCI019702; -.
DR VEuPathDB; VectorBase:ISCP_019587; -.
DR VEuPathDB; VectorBase:ISCP_026480; -.
DR VEuPathDB; VectorBase:ISCW019702; -.
DR HOGENOM; CLU_504612_0_0_1; -.
DR InParanoid; B7PVN6; -.
DR OMA; HICKIRL; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR CDD; cd18989; LGIC_ECD_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 2.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF942; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA6, ISOFORM E; 1.
DR Pfam; PF02931; Neur_chan_LBD; 2.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 2.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT TRANSMEM 103..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 423..444
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 450..471
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 4..45
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 222..384
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
SQ SEQUENCE 495 AA; 56097 MW; 30676FF445EB4D03 CRC64;
MPTTAYLDHN GEVWYCPPSK IKVACGMDVR RFPFDAHICK IRLSSEDDQV KLSGRPLHPS
ALPLSRNASS VWSLKSITFS DSQVLNMACL DIAFEVERRS HHYLYDVTLP WASSFVLTLV
VFWLPADSDR RLTLVGLNLV FITQIMWRVT SLFVIYLGNA ILIEAIVAVS TVVILNMATA
PVPARIPDAV VRFLSGPIGP LLCLRHYSEL DEEYVSHSQL LRTKLFDPSK YDVHRRPTKD
NSSATEVSLH FYGEEVAYMN LQDDWLALAM VTCKKWYDRT LRWNRGDYGG LQSIDVFLSE
IWSPDIQIVN TNPDDYTPQT IMASLFHDGE LWFCQTATVK VPCPMDLTDY PFDSQVCRIR
FALLAYEDDE VRLGGEGTLN PSVTNQSSEW QVTFLDTSHG TLLNKTSLDI IIGMKRRCTH
HRYTATLPWV ASVIMMLLGF WMPANSSRRL TLACINLLLI MLMLQRITVL LKTSSAVPKI
GGFFVLSNND LHAFV
//
