ID B7PWE2_IXOSC Unreviewed; 358 AA.
AC B7PWE2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW007846 {ECO:0000313|EMBL:EEC10914.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC10914.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC10914.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW007846-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW007846-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR EMBL; ABJB010445356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS807640; EEC10914.1; -; Genomic_DNA.
DR RefSeq; XP_002409704.1; XM_002409660.1.
DR AlphaFoldDB; B7PWE2; -.
DR STRING; 6945.B7PWE2; -.
DR PaxDb; 6945-B7PWE2; -.
DR EnsemblMetazoa; ISCW007846-RA; ISCW007846-PA; ISCW007846.
DR KEGG; isc:IscW_ISCW007846; -.
DR VEuPathDB; VectorBase:ISCI007846; -.
DR VEuPathDB; VectorBase:ISCP_012881; -.
DR VEuPathDB; VectorBase:ISCW007846; -.
DR HOGENOM; CLU_006586_13_0_1; -.
DR InParanoid; B7PWE2; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003990; F:acetylcholinesterase activity; IBA:GO_Central.
DR GO; GO:0006581; P:acetylcholine catabolic process; IBA:GO_Central.
DR GO; GO:0019695; P:choline metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR PANTHER; PTHR43918:SF4; CARBOXYLIC ESTER HYDROLASE; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT DOMAIN 8..342
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC10914.1"
FT NON_TER 358
FT /evidence="ECO:0000313|EMBL:EEC10914.1"
SQ SEQUENCE 358 AA; 40404 MW; 85C5ADDF6E29E08D CRC64;
GDSALFIYDP ANFVALSNVV FVTFNYRVSI FGFLSLEKPE RLGNMGLWDQ NLVLKWVQKN
IEHFGGDPNE VTLSGQSAGA ISVGLHAVAP PSQGLFKRVI MESGTPLSMI LGMSYRGVSK
FTHIAGALGC YDTRLSFNEQ LDKVMACLRN LDARFIIKIL ASVDDVQRMF SPIHGDDFLP
QHVLSEKTWT SLSFKNVLIG TNRDEGSLFL DHLKFSFPRL EQVMSGDYRL AITFALAPVF
NIPVSKVKHL VNFYFGGYET KHDTKTVVDI FGKIFGDAVF DCPTQLFAET IARQGISTYR
YLFAYESTFS FWPDWMGVVH AEELAYTLGS LPFYKDSDRY TEPLDDYEKE QLAKIQYT
//
