ID B7PWF1_IXOSC Unreviewed; 964 AA.
AC B7PWF1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Apical endosomal glycoprotein, putative {ECO:0000313|EMBL:EEC10923.1};
GN ORFNames=IscW_ISCW008401 {ECO:0000313|EMBL:EEC10923.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC10923.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC10923.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW008401-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW008401-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; ABJB010154977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010202901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010304431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010473281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010485463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010633893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010669958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010840591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010981449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011046137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS807745; EEC10923.1; -; Genomic_DNA.
DR RefSeq; XP_002409744.1; XM_002409700.1.
DR AlphaFoldDB; B7PWF1; -.
DR PaxDb; 6945-B7PWF1; -.
DR EnsemblMetazoa; ISCW008401-RA; ISCW008401-PA; ISCW008401.
DR KEGG; isc:IscW_ISCW008401; -.
DR VEuPathDB; VectorBase:ISCI008401; -.
DR VEuPathDB; VectorBase:ISCW008401; -.
DR HOGENOM; CLU_307015_0_0_1; -.
DR InParanoid; B7PWF1; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd00112; LDLa; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF146; ENDOSOMAL GLYCOPROTEIN PRECURSOR, PUTATIVE-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00629; MAM; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 2.
DR SMART; SM00137; MAM; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS50060; MAM_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 176..398
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 439..640
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 702..878
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DISULFID 423..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 680..695
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 964 AA; 107495 MW; 514EB02880AEFAFB CRC64;
MELRQVDYKD ESGVPSTLQT VQLPAAEAWQ TTQLKLKPSQ DSQIIIALTR GKGSNGIAAV
GVISGRFIYA EHLGAKYATA RLKSPEIPTD VRNEFCVSLW HAALPRTKGF ISLNDTVWSN
PLLRDHSRTI HHWAHDLVQM KLPEDVDRFT IDAHMISGLI ALDDLVLTPG QCPMPNKCTF
EIFSPCRFNT EFTSPRLWYI GRSRVLNIPD HTMQDSTGHF LYVNTTVVDP AHPEARVFLE
HRGPSPATCV TFWWKGIGKP SDLNLVFEAV SFPYFSGQSG VMVDDVEFTD GECPPESHYL
LFRGTGNVID SAVLELRERR FQCASFWYFI SESSSGCRIE VGDNVLRNAT QGWKHYTSDL
SLSWVLQYGV TIRAYSGTDD TAFVAIDDIR VDERRCTEHD TVITDDFVCS ITTEETVPMD
KVCNFVKDCS NGVDEADCGS CDFRSTPCGW DLGRLRDKGL PSWQRRQVGE IPGSPKLNHD
DTTNGFYMIF AGEEESKHVV ERAIASAPII RNTDYLCLFT FWYNYASRFL IFRSSETAVK
SEIAGPILQA NDTCAITFFY TIYNGASSRL ILGVRHTIGG PLTEIWSTGK LDTSFDFLGH
FEYLREERPF QVFFKGEHRA TDEASYIAID DVSFTSGCRP YHGTLPIEPP TPAPTDTPTC
PQGQFVCVTS RQCIPQSQVC DFKQHCPDGS DERDCGSLIS TGACDFSTDL CGLRTDNPDA
KYTWNRISAK DVSKKPAGNY GLPKTDSTND PDGFYCAFRH TNRGPYMYIT NHGAEEGRGH
LVSKRLGASG PAGRCFSFWY NMRHPNSGRL SLLARSEDNS TELLWTRSGP QGRAWLRGYA
DAHSDSYSHF VLEAVLPGST PAVIAVDHID VRGGECKSKG KYARLAKSYG RLVSPEVRVP
PSAGRCVKFW YYLSGGDGEQ LNVSRVTDFQ REEPIWSVLA SQGPPMTWLS GSVNLLGHQG
PLAR
//
