ID B7PXK0_IXOSC Unreviewed; 499 AA.
AC B7PXK0;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Adenosine diphosphatase, putative {ECO:0000313|EMBL:EEC11322.1, ECO:0000313|EnsemblMetazoa:ISCW010120-PA};
DE EC=3.6.1.5 {ECO:0000313|EMBL:EEC11322.1};
GN ORFNames=IscW_ISCW010120 {ECO:0000313|EMBL:EEC11322.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC11322.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC11322.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW010120-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW010120-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR EMBL; ABJB010794600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010894323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS814574; EEC11322.1; -; Genomic_DNA.
DR RefSeq; XP_002401003.1; XM_002400959.1.
DR AlphaFoldDB; B7PXK0; -.
DR STRING; 6945.B7PXK0; -.
DR PaxDb; 6945-B7PXK0; -.
DR EnsemblMetazoa; ISCW010120-RA; ISCW010120-PA; ISCW010120.
DR KEGG; isc:IscW_ISCW010120; -.
DR VEuPathDB; VectorBase:ISCI010120; -.
DR VEuPathDB; VectorBase:ISCP_033638; -.
DR VEuPathDB; VectorBase:ISCW010120; -.
DR HOGENOM; CLU_010246_2_3_1; -.
DR InParanoid; B7PXK0; -.
DR OMA; GSANECH; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004050; F:apyrase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF3; APYRASE 6-RELATED; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000313|EMBL:EEC11322.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PXK0};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 81..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 234
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 267..271
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 499 AA; 53936 MW; 7DBD5D87314D515E CRC64;
MEVHLQCVAR PDLAPMTVRT HAGATADSLL GAFWHECGIA YDPALALYTR SNRPLRPGAS
LNALGVRSGD TLYLRRQRAP LLFLANWGLL AVVCGVVALL GLLLASMAYG LTGGRVPFVH
GVVVDAGSSH TEATLYRWQG AKYLGTGRAV QVDHAESDGG ISTMEPRRTA EDLARAVSGL
LGGIRAPVYL GATAGMRVLN LTQPAQADAI LMAAECALKP YGLRRAVILS GHDEGVFAWL
STNYLVEVIP QDSGHTEDTF GALDLGGAST QVAFPVSSDA SSEDITELTL YGRKYRVFAV
SYLCYGVNEI RRRFLAHIIA QQEYRDTIVS PCHNSGYTFN LTAKDIFESY CTITPQTESW
LQQHPDAVFT FVGNGSANEC HSAVADLMNP ATCKKSYSTC LEPPKVPVPT GQKYMAFSAF
YYTLKALNAT GMPLDTFLNN SNLMCSATWE EAQTLPSAPT VGFHLFVLLL CLFVGLLMLA
AAFLVLARKQ SRAKLHPPM
//
