ID B7Q273_IXOSC Unreviewed; 153 AA.
AC B7Q273;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Gaba-B receptor, putative {ECO:0000313|EMBL:EEC12945.1, ECO:0000313|EnsemblMetazoa:ISCW020862-PA};
GN ORFNames=IscW_ISCW020862 {ECO:0000313|EMBL:EEC12945.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC12945.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC12945.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW020862-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW020862-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ABJB010001291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010032095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010045285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010326460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010334474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010359204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010760377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS842011; EEC12945.1; -; Genomic_DNA.
DR RefSeq; XP_002410543.1; XM_002410498.1.
DR AlphaFoldDB; B7Q273; -.
DR STRING; 6945.B7Q273; -.
DR PaxDb; 6945-B7Q273; -.
DR EnsemblMetazoa; ISCW020862-RA; ISCW020862-PA; ISCW020862.
DR KEGG; isc:IscW_ISCW020862; -.
DR VEuPathDB; VectorBase:ISCI020862; -.
DR VEuPathDB; VectorBase:ISCP_016888; -.
DR VEuPathDB; VectorBase:ISCW020862; -.
DR HOGENOM; CLU_050795_1_0_1; -.
DR InParanoid; B7Q273; -.
DR OMA; QDENMRY; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EEC12945.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..99
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 153 AA; 17446 MW; 323266E10EDC709C CRC64;
MEFCQSQKMT IFLGSIYAYK GLLMAFGCFL AWETRHVSIP ALNDSKYVGM SVYNVVIMCS
IGAAISFVLR DQQDAAFIII SVFIIFCSTT TLCLVFVPKA GEHRVRATLK PLKKSRRDSD
DESLFTRIKV LQDENMRYRQ RLEEGSYLAI FSN
//
