ID B7Q2J4_IXOSC Unreviewed; 195 AA.
AC B7Q2J4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Spaetzle domain-containing protein {ECO:0000259|Pfam:PF16077};
GN ORFNames=IscW_ISCW008795 {ECO:0000313|EMBL:EEC13066.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC13066.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC13066.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW008795-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW008795-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010045803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010715087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010834345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS844506; EEC13066.1; -; Genomic_DNA.
DR RefSeq; XP_002410846.1; XM_002410801.1.
DR AlphaFoldDB; B7Q2J4; -.
DR STRING; 6945.B7Q2J4; -.
DR PaxDb; 6945-B7Q2J4; -.
DR EnsemblMetazoa; ISCW008795-RA; ISCW008795-PA; ISCW008795.
DR KEGG; isc:IscW_ISCW008795; -.
DR VEuPathDB; VectorBase:ISCI008795; -.
DR VEuPathDB; VectorBase:ISCP_037170; -.
DR VEuPathDB; VectorBase:ISCW008795; -.
DR HOGENOM; CLU_1397767_0_0_1; -.
DR InParanoid; B7Q2J4; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005121; F:Toll binding; IBA:GO_Central.
DR GO; GO:0021556; P:central nervous system formation; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 2.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR032104; Spaetzle.
DR PANTHER; PTHR23199:SF12; NEUROTROPHIN 1-RELATED; 1.
DR PANTHER; PTHR23199; UNCHARACTERIZED; 1.
DR Pfam; PF16077; Spaetzle; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 96..189
FT /note="Spaetzle"
FT /evidence="ECO:0000259|Pfam:PF16077"
SQ SEQUENCE 195 AA; 22641 MW; 7D7CEF5B81158ED7 CRC64;
MDGGDCGRKA TGMRPATWVE NYTLAFAQEK QHGSFVCRSE AVYLRIGWAK NWKGLWLTVV
NTERFPQVTR VEKCKSVQWV ENYTLAFAQE KQHGSFVCRS EAVYLRIGWA KNWKGLWLTV
VNTERFPQVT RVEKCKYRGK PCDYMVPCYK SSCKQREMLF PLIAVNPYDP GQKPSIELFP
IPSGCVCYVD DFRFH
//
