ID B7Q3E5_IXOSC Unreviewed; 363 AA.
AC B7Q3E5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=Citrate lyase beta chain, putative {ECO:0000313|EMBL:EEC13367.1, ECO:0000313|EnsemblMetazoa:ISCW009007-PA};
DE EC=4.1.3.34 {ECO:0000313|EMBL:EEC13367.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW009007 {ECO:0000313|EMBL:EEC13367.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC13367.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC13367.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW009007-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW009007-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; ABJB011001546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS849387; EEC13367.1; -; Genomic_DNA.
DR RefSeq; XP_002411243.1; XM_002411198.1.
DR AlphaFoldDB; B7Q3E5; -.
DR STRING; 6945.B7Q3E5; -.
DR PaxDb; 6945-B7Q3E5; -.
DR EnsemblMetazoa; ISCW009007-RA; ISCW009007-PA; ISCW009007.
DR KEGG; isc:IscW_ISCW009007; -.
DR VEuPathDB; VectorBase:ISCI009007; -.
DR VEuPathDB; VectorBase:ISCP_021971; -.
DR VEuPathDB; VectorBase:ISCW009007; -.
DR HOGENOM; CLU_044864_1_1_1; -.
DR InParanoid; B7Q3E5; -.
DR OMA; AWLFCPA; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0008816; F:citryl-CoA lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IBA:GO_Central.
DR GO; GO:0006107; P:oxaloacetate metabolic process; IBA:GO_Central.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR InterPro; IPR040186; Citramalyl-CoA_lyase.
DR InterPro; IPR011206; Citrate_lyase_beta/mcl1/mcl2.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR11105:SF0; CITRAMALYL-COA LYASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11105; CITRATE LYASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF03328; HpcH_HpaI; 1.
DR PIRSF; PIRSF015582; Cit_lyase_B; 1.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE 1: Evidence at protein level;
KW Lyase {ECO:0000313|EMBL:EEC13367.1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR015582-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR015582-2};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7Q3E5};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 45..273
FT /note="HpcH/HpaI aldolase/citrate lyase"
FT /evidence="ECO:0000259|Pfam:PF03328"
FT REGION 334..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 107
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT BINDING 172
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
FT BINDING 172
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT BINDING 207
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC13367.1"
SQ SEQUENCE 363 AA; 40910 MW; A6E651F7CC9EA661 CRC64;
LLLQMLRQFF RRDLSSQLRL CSLLPRRYKS DDNATPTRKK YTPRRAVLYV PGNDEKKIVK
TTNLDVDCVV LDCEDGVAVN KKKEARETIG KVLGSLQFGA RTDVAVRVNS VGSGLAEEDL
ECILEAKTLP STIFLPKVES KDDVTWLMNH VQSELKDRKR DKHKFDLVLY VETALGLLNC
REFLEHTREM SEFTRFRLAG LVFGSDDFTA NIGATRTKDA KEVLFARQQV VVLAKAYGIQ
AIDMLYFKNL EGLRAHSLEG ASMGFTGKQV IHPGQVAVVQ EAFSPSPEQL DRARRMVAQF
EKHQKEGKGA FTFEGSMIDM PTVLQATNLV EADRAIHASR ENKDGEENSS DDEKHQKKAK
KES
//